Neurobiology
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Dynamic changes in Hox Gene Expression during Somite and Neural Tube Development
(2025)"Mammalian embryonic development is when body pattern is established and all organs are formed. Hoxa5 is expressed in lung, neural tube, somites, diaphragm, foregut, midgut, and patterns the cervical-thoracic region of ... -
Glioblastoma Immunotherapy: Investigating the Role of Dendritic Cells in GIFT7-Induced TH17 Differentiation
(2025)"Glioblastoma (GBM) remains a highly aggressive and incurable brain tumor with limited treatment options. Immunotherapy, particularly tumor vaccines, has shown promise in other cancers but remains ineffective in GBM due ... -
Cognitive and sensory performance in a rhesus model of frontotemporal dementia
(2025)"Frontotemporal dementia (FTD) is a group of neurodegenerative disorders affecting the frontal and temporal lobes of the brain. FTD is highly hereditary and is the most common dementia in patients under 60 years old. Dr. ... -
Ponatinib suppresses NLRP3 inflammasome activation in primary microglia
(2025)Alzheimer’s Disease (AD) is a neurodegenerative disease affecting 6.9 million people in the United States. AD pathology is characterized by extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tau ... -
The Impact of CAR T-cell Target Antigens on IFNγ Dependence in AML vs B-ALL
(2025)Chimeric antigen receptor (CAR) T-cell therapy has revolutionized treatment of B-cell acute lymphoblastic leukemia (B-ALL) but has not been successful in acute myeloid leukemia (AML), likely in part due to differences in ... -
Characterizing Individual Differences in Behavior and Neural Activation Through the Organization of Social Semantic Information
(2025)This thesis investigates whether individual differences in the semantic organization of social information correspond to differences in neural activation. Building on recent critiques of the assumption of cognitive ... -
Membrane Remodeling and Neuronal Development: Investigating the HR1 Domain’s Role in CIP4 Function
(2025)F-BAR domain proteins play a crucial role in membrane remodeling and actin cytoskeletal regulation. This thesis investigates the functional role of the HR1 domain in the F-BAR protein CIP4 and its impact on membrane tubule ... -
Evaluation of Infant Motor Development Following Perinatal Injury to Somatosensory Versus Motor Cortex
(2025)Cerebral palsy is the most prevalent childhood motor disorder, affecting approximately 1 in 345 children in the United States (CDC). Perinatal brain injury is a primary cause of cerebral palsy, but little is known about ...
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