Investigating the Role of SDHB in Cardiac Regeneration
Date
2023Author
Nahlawi, Raya
Advisor(s)
Mahmoud, Ahmed
Paltzer, Wyatt
Metadata
Show full item recordAbstract
Heart failure is the leading cause of death in the United States. The long wait for heart
transplants and the risk of graft rejection has motivated heart regeneration research to advance
heart failure treatment. Importantly, it has been established that loss of cardiac regeneration is
associated with a metabolic switch from glycolysis to oxidative phosphorylation. Additionally,
succinate dehydrogenase (SDH) is a central enzyme in mitochondrial metabolism. Previous
research has implicated pharmacologic SDH inhibition with cardiac regeneration. However, it
remains unknown whether cardiomyocyte-specific inhibition of SDH by genetic deletion of SDH
Complex subunit B (SDHB) can promote heart regeneration following myocardial infarction
(MI). Therefore, this study investigates the role of SDHB in cardiomyocyte proliferation and
heart regeneration following MI injury to better understand cardiac metabolic regulation
following injury and identify a potential metabolic target for heart failure treatment.
Permanent Link
http://digital.library.wisc.edu/1793/84961Type
Thesis