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Prospects for development of an effective Lyme disease vaccine
(2016-09-14)
Lyme disease is the most prevalent tick-borne disease in the world, and the annual number of cases continues to increase. By this measure, a vaccine to prevent the illness would be valuable. However, the first commercial ...
Regulation of OspC Expression in a B. burgdorferi Isolate
(2016-09-14)
Lyme disease causes significant morbidity in the US, and there is currently no effective vaccine. Among the most promising strategies are an OspC-based vaccine, but development has been significantly hindered by the extreme ...
Allochthonous carbon delivery from the invasive grass (Phalaris arundiancea L.) to a lotic ecosystem
(2017-05)
Reed canarygrass (RCG; Phalaris arundiancea L.;) invades wetlands throughout the United States of America, including floodplain forests (FPF) found along the upper Mississippi River (UMR). This study was done to determine ...
Upregulation of outer surface protein c expression by Lyme disease spirochetes in laboratory medium
(2015-12)
Lyme disease is the most common vector borne illness in the United States and there is considerable interest in the ability of vaccination with OspC to provide protection. However, studies to evaluate the efficacy of this ...
Increase of extracellular matrix proteins in hibernating ground squirrels could help maintain bone health
(2018-12)
Whether from injury, old age, or space flight, immobility or a lack of gravitational loading has negative effects on the physiology of bone and bone marrow. Consequences include a weakening of the immune system, decreased ...
Eating and appetite regulating hormones in women with polycystic ovary syndrome and weight-matched controls
(2017-02-07)
Background: Polycystic ovarian syndrome (PCOS) is a common condition in women that affects health and fertility. It is characterized by hyperandrogenism, insulin resistance, and oligo- or anovulation. Insulin resistance ...
13-lined ground squirrel platelets exhibit rod conformation that reduces rates of liver cell phagocytosis
(2019-12)
Thrombocytopenia, or low levels of platelets in blood, is a symptom of various conditions and is typically treated via platelet transfusions. Donated platelets must be stored at room temperature due to structural damages ...
Genetic and genomic insights into the successional patterns and reproduction methods of fire-associated Morchella
(2020-05)
Burn morels are among the earliest-emerging post-fire organisms in western North American montane coniferous forests, occurring in large numbers the year after a fire. Despite their significant economic and ecological ...
Effects of the stress-related neuropeptides urocortins on colonic epithelial barrier function
(2019-05)
Urocortins (Ucn1, Ucn2, and Ucn3) belong to the corticotropin-releasing factor (CRF) peptide family which exert their actions on two CRF receptors subtypes (CRF1 and CRF2). Ucn1 binds to CRF1 and CRF2, whereas Ucn2 and ...
Optimization of chondrogenic potential in transplanted adipose-derived stem cells for treatment of osteoarthritis
(2019-05)
Importance: Osteoarthritis (OA) has, and will continue to be, the leading form of musculoskeletal disease in the United States. More pragmatic and less invasive techniques for treating OA are required if physicians are to ...