Now showing items 1-10 of 45
Analysis of the Antibody Binding of Derivative MUC1 Peptides via STD NMR
This study analyzes the binding ability of the peptide GVTSAPD, an upstream sequence preceding PDTRP, as well as six derivative peptides against specific mouse MUC1 mucin monoclonal antibody (IgG1, 6A4) by Saturation ...
Purification of Copper-Free Methanobactin-SB2 to Analyze its Shape-Shifting Behavior
We are interested in isolating the copper-free forms of methanobactin, which presents a challenge, since they are much more unstable and difficult to characterize than the copper bound forms that we and others have worked ...
Synthesis of Cyclic Antigenic MUC1 Mimotopes
The immune system responds to antigens via specific sequences called epitopes. The antibody binding amino acid epitope PDTRP within the variable tandem repeat (VNTR) domain of the Mucin1 (MUC1) transmembrane epithelial ...
Metal Sequestration During Aggregation Based Crystal Growth
This project is focused on determining how associated metals of environmental concern (especially Pb) behave during aggregationbased crystal growth as a function of increasing Crystallinity Index (CI).
Synthesis and Antibody Binding Study of MUC1 Mucin Peptides with Unnatural Backbones
The MUC-1 mucin is a heavily glycosylated transmembrane protein found on the apical surface of epithelial cells with a short cytoplasmic end and a longer extracellular domain consisting of multiple 20-amino acid tandem ...
Smart Diblock Copolymers for Enhanced Oil Recovery Applications
The purpose of this study was to examine the benefits and drawbacks of enhanced oil recovery (EOR).
Computational Docking of Mucin Peptide Derivatives with SM3 Antibody
The crystal structure of the mucin monoclonal antibody SM3 complexed with a 13 amino acid MUC1 mucin peptide was determined. The high selectivity of the SM3 antibody to the aberrant carbohydrate cancer mucin peptide suggests ...
Investigating Catalytically Important Residues in Escherichia coli Prolyl-tRNA Synthetase Through Site-Directed Mutagenesis
In the present study, we have employed site-directed mutagenesis to probe the role of four residues in E. coli ProRS (Ec ProRS) on the overall catalytic function. Specifically, we examined the impact of changes in amino ...
Use of Geometrical Docking Algorithm to Explore Species Specific Differences in Proyl-tRNA Synthetases
Prolyl-tRNA synthetases belong to a class of enzymes that play a pivotal role in the protein synthesis. These enzymes are responsible for attaching the amino acid, proline, to the 3’ end of the prolyl-tRNA. The structures ...
Synthesis, Characterization and Applicability of Reactive Biomimetic Complexes Towards Important Biological Reactions
This study involves the development, synthesis, and characterization of new biomimetic model systems consisting of a tetra-dentate N3[subscript]O-containing ligand (BPG) and divalent first-row transition metal ions observed ...