Browsing Biology Honors Theses and Research Papers by Title
Now showing items 1-20 of 53
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Activation and suppression of macrophages: implications for cancer immunotherapy
(2006)It is widely known that macrophages can be activated to kill tumor cells. It is also known that tumor-infiltrating macrophages can be immunosuppressed. The mechanisms of both tumor killing by activated macrophages and ... -
ANTITUMOR EFFECTS OF ANTl-CD40/CPG IMMUNOTHERAPY COMBINED WITH GEMCIT ABINE OR 5-FLUOROURACIL CHEMOTHERAPY IN THE B 16 MELANOMA MODEL
(2013)Our previous studies demonstrated that anti-CD40 mAb (anti-CD40) can synergize with CpG oligodeoxynucleotides (CpG) to mediate antitumor effects by activating myeloid cells such as macro phages in tumor-bearing mice. ... -
Attempts to analyze the RNA-binding specificity of the C. elegans RNP-8 protein
(2010)Cytoplasmic polyadenylation is a key mechanism of gene regulation in all eukaryotes. The C. elegans GLD-2 protein provides the catalytic activity for a cytoplasmic poly(A) polymerase, but GLD-2 must partner with another ... -
AXL mediates the nuclear translocation of EGFR
(2015)Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that has shown efficacy in numerous cancer types. Clinical data suggests that patients whom initially respond to cetuximab eventually acquire ... -
Bacterial Community Spatial and Temporal Variation in a North Temperate Bog Lake
(2012)Bog lakes such as Mary Lake in northern Wisconsin are ideal systems to investigate microbial communities due to easily identified spatial boundaries and well characterized seasonal ecosystem dynamics. Multiple factors are ... -
Bacterial strains within the fungus gardens of leaf-cutter ants show evidence of mutual and commensal interactions
(2017-06-13)Leaf-cutter ants have a symbiotic relationship with a fungal cultivar known as Lecuoagaricus gongylophorus. The cultivar functions as an external gut by breaking down plant polysaccharides and supplies the ants with simple ... -
The Biochemical Characterization of a Translational Repressor
(2008)Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ... -
Comparison of non-heme liver iron and iron metabolism protein levels in superoxide dismutase 1 knock-out mice versus superoxide dismutase 1 wild-type mice
(2007)Iron is an important micronutrient that is necessary for multiple cellular functions. However, iron levels must be tightly regulated in order to prevent iron-deficiency and iron-toxicity. There are many proteins involved ... -
Delta-opioid receptor (DOR) activation prolongs respiratory motor output during oxygen-glucose deprivation (OGD) in neonatal rat spinal cord in vitro
(2007)Severe reduction of blood flow to the brain results in oxygen-glucose deprivation (OGD) and neuronal damage. DOR activation is neuroprotective during OGD in the cerebellum and cortex, but it is not known whether DOR ... -
Determining the impacts of residential lakeshore development and various physical factors on largemouth bass (Micropterus salmoides) growth rates
(2007)Development of residential lakeshore properties can have several effects on aquatic ecosystems including the thinning of littoral coarse woody habitat. Previous studies have shown that reduction of littoral coarse woody ... -
Do IRX3 and IRX5 Direct Cytoplasm Traffic Between Oocytes During Germline Cyst Breakdown?
(2023)Poor oocyte quality and a diminished ovarian reserve contribute significantly to female infertility. The ovarian reserve is determined by the finite supply of primordial follicles a woman has at birth. Evidence suggests ... -
E. coli contaminated drinking water in rural Uganda: Using results to make an impact
(2007)In January 2006, I worked with Community Based Integrated Nutrition (COBIN) to perform water quality testing and design & distribute health questionnaires to 40 households in the Lyantonde and Kiruhura districts of rural ... -
The effects of 1,25 D3 on the mouse osteopontin promoter
(2007)Vitamin D (1,25 D3) is an important transcriptional regulator of many genes including our gene of interest, osteopontin. Osteopontin is a known regulator of bone calcification and mineralization and is involved in signaling ... -
The effects of inter-personal factors on bird and bat mortality searcher efficiency
(2010)Employee efficiency and performance are essential to the success of a project. These inter-personal factors have been investigated in specific settings but have not been explored in the scientific research assistants. This ... -
The Emotional Body: The Intersection Between Embodied Emotional Awareness, Empathy, Alexithymia, Well-Being and Altruism
(2017-05-15)Emotion regulation and empathy are critical components for human social interaction and may help determine who is resilient when faced with challenging psychosocial situations and who may be vulnerable. Recent evidence has ... -
Examining cell shape as the mechanism for furrow positioning in the early Zebrafish (Danio rerio) embryo
(2010)Through previous studies, it has been found that Zebrafish embryos show a predictable pattern of cell division consisting of the spindle apparatus always aligning perpendicular to its orientation in the previous cell stage. ... -
Exploring Senataxin -- Sen1p homology
(2010)Mutated SETX, a human gene encoding for the protein Senataxin, has been identified among patients with two different neurodegenerative disorders--ataxia-ocular apraxia 2 (AOA2) and amyotrophic lateral sclerosis 4 (ALS4). ... -
Feasibility study: Comparison of performance status with objective physical activity monitors in lung cancer patients
(2010)Context: Performance status (PS) is a predictor of response to chemotherapy but difficult to identify in patients with advanced lung cancer. It is measured using the ECOG scale, which relies on simple questions to assign ... -
Gaze-evoked blinks in rhesus monkeys
(2007)Gaze-evoked blinks, blinks that occur during rapid movements of the head and eyes, are believed to be the result of a shared mechanism that is responsible for a blink occurring with a saccade. In humans, it has been found ... -
GBT440 increases hematocrit and improves biventricular function in Berkeley sickle cell disease mice
(2020-05)Sickle cell disease (SCD) is a hereditary blood disorder affecting millions of people in which red blood cells become sickled and lyse easily driven by polymerization of hemoglobin. Chronically, SCD causes anemia and ...