Using AutoDeck Vina to Create a Quercetin Derivative for Binding Xanthine Oxidase
Abstract
Quercetin is an anti-hyperuricemia agent that competitively inhibits the natural ligands for binding at the active site of Xanthine Oxidase (XOD), which catalyzes the oxidation of hypoxanthine to xanthine and then to urate. It is an old treatment for gout, a disease resulting from the buildup
of uric acid crystals in the joints of limbs. The purpose of this study is to find a water soluble quercetin derivative with higher affinity for the XOD active site.
Subject
Xanthine oxidase (XOD)
Quercetin
Posters
Permanent Link
http://digital.library.wisc.edu/1793/76052Type
Presentation
Description
Color poster with text, images, graphs, models, and tables.