We have uncovered how Epstein-Barr virus (EBV) induces the reorganization of cellular chromatin (ROCC), where host chromatin is compacted and marginated within the nucleus. We tested the role of EBV lytic DNA amplification ...

Splicing of pre-mRNAs is an essential process for regulation of eukaryotic gene expression. Splicing is carried out by the spliceosome, a highly dynamic complex. Mutations within the spliceosome are responsible for various ...

Steroidogenic acute regulatory protein (StAR) is a transport protein which plays a key role in steroidogenesis. Different pathways can activate StAR transcription. cAMP activates PKA which phosphorylates CREB. PKA also ...

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Despite a majority of proteins depending on the early secretory pathway for export, the precise role of this machinery in development and maintenance of tissue architecture is largely unknown. The p.R106C mutation in ...

Milk proteins are produced in mammary epithelial cells from amino acids (AA). Excess AA that are not used for protein synthesis are excreted by the cow as nitrogenous (N) waste products through urine. Excretion of N waste ...

Understanding the cellular and molecular mechanisms of regenerative zebrafish will advance fundamental knowledge of tissue regeneration. Our previous study identified scn8ab, which encodes a voltage-gated sodium channel, ...

The dedifferentiation of pancreatic (3-cells commonly occurs in the pathogenesis of both type 1 and type 2 diabetes. The (3-cell identity undergoes unique changes depending on the diabetogenic stress that is encountered. ...

Stroke is a leading cause of death, as onset induces an innate immune response using Toll-like receptor 4 (TLR4), which promotes inflammation and blood-brain barrier (BBB) permeability. TLR4 is a receptor for high-mobility ...