Browsing Biochemistry Honors Theses and Research Papers by Title
Now showing items 1-20 of 84
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Analysis of StAR RNA Splicing and Lipid Droplets Composition in MA10 Cells Under Different Stimuli
(2023)Steroidogenic acute regulatory protein (StAR) is a transport protein which plays a key role in steroidogenesis. Different pathways can activate StAR transcription. cAMP activates PKA which phosphorylates CREB. PKA also ... -
Analyzing interactions between the GV1 Cell Line, Juvenile Hormone, and Juvenile Hormone Binding Protein
(2011)Insect juvenile hormone (JH) and its hemolymph transport protein, juvenile hormone binding protein (JHBP) play key roles in the development of many insects. However, the exact mechanism via which JH and JHBP regulates ... -
Angiopoietin-2 Levels increase following Oxygen Glucose Deprivation (OGD) and Reperfusion in Brain Microvascular Endothelial Cells
(2022-02)Stroke is a leading cause of death, as onset induces an innate immune response using Toll-like receptor 4 (TLR4), which promotes inflammation and blood-brain barrier (BBB) permeability. TLR4 is a receptor for high-mobility ... -
The Apoptotic Role of Cpeb1 in INS-1 Cells
(2022)The dedifferentiation of pancreatic (3-cells commonly occurs in the pathogenesis of both type 1 and type 2 diabetes. The (3-cell identity undergoes unique changes depending on the diabetogenic stress that is encountered. ... -
Bioassay-guided purification and characterization of anti-inflammatory components in Cinnamomum burmannii
(2010)Excessive inflammatory response is implicated in many diseases such as arthritis, atherosclerosis, and cardiomyopathy. Previous studies have found that several cinnamon species could exhibit anti-inflammatory activities. ... -
Chamber-related variation in phosphorylation state of cardiac troponin revealed by high resolution top-down mass spectrometry
(2010)Cardiac troponin complex (cTn) is a key regulator of Ca-2+- mediated cross-bridge cycling in cardiac muscle. Post-translational modifications, especially phosphorylation of cTn, are major mechanisms in modulation of ... -
Characterization of Putative RpoS-regulated Outermembrane Proteins Slp and OmpX in Escherichia coli 0157:H7
(2012)E. coli 0157:H7 is a food pathogen with exceptional tolerance to certain stressful growth conditions. RpoS is a master regulator for bacterial stress adaptation and in particular, for acid resistance genes. The role of ... -
Characterization of Tau Phosphorylation During the Differentiation of Human Embryonic Stem Cells
(2008)Alzheimer's disease is the seventh leading cause of death in the United States with an estimated cost of 100 billion dollars. The severity of this neurodegenerative disease is strongly correlated with the number of ... -
Characterization of ZIIR element of BZLF1 promoter in the context of the whole Epstein - Barr Virus genome
(2007)Latent infection of Epstein-Barr virus (EBV) is associated with many human cancers. Induction of lytic replication of EBV may lead to destruction of these tumor cells. The viral immediate-early gene, BZLF1, plays a key ... -
Characterizing the nucleotide-binding domain of Escherichia coli HscA, a specialized Hsp70 chaperone in Fe-S cluster biogenesis
(2014-05)Proteins from the ISC operon of E. coli constitute the machinery used for the synthesis of iron-sulfur clusters and their delivery to recipient apo-proteins. [2Fe-2S] cluster transfer from the holo-scaffold protein lscU ... -
Chronic and acute seizure activity affects NKCC1 and KCC2 expression and alters GABA-induced inhibition in the adult and developing hippocampus
(2008)Temporal lobe epilepsy is a relatively common nervous system disorder characterized by abnormal activity in the hippocampus, often caused by a decrease in GABA inhibition. GABAA receptors are Cl- ion channels whose effects ... -
Cleavage and Polyadenylation Specific Factor 6 (CPSF6): A possible protein mediator for CARM1 and pre-MRNA splicing
(2008)Coactivated associated methyltransferase 1 (CARM1), an enzyme that regulates cellular processes via arginine methylation, has been suggested to play a role in RNA processing and alternative splicing. The focus of this ... -
Defining the molecular determinants required for RNA binding functions of the Bicaudal-C (Bicc1) translational repressor protein
(2020-05)Bicaudal-C (Bicc1) is an RNA binding protein that functions as translational repressor in all animal species. Its repression activities are required for a multitude of biological processes such as guiding the earliest steps ... -
Defining the PIPKIgamma707/SNX5 interaction and its possible association with E-cadherin
(2008)E-cadherin, a cell adhesion molecule and tumor suppressor plays an important role in suppressing metastasis of cancers of epithelial origin by acting as the cornerstone of adherens junctions, which facilitate adhesion ... -
Determining the minimal nutrient requirements for the swarming phenotype in Escherichia coli and other swarming bacterial species
(2010)This project lays the foundation for identifying chemical inducers and inhibitors in swarming cells of Escherichia coli. Swarming is a type of cell surface motility characterized by differentiated bacterial cells that have ... -
Determining the requirement for viral DNA amplification in mediating the reorganization of cellular chromatin during the Epstein-Barr virus lytic cycle
(2023)We have uncovered how Epstein-Barr virus (EBV) induces the reorganization of cellular chromatin (ROCC), where host chromatin is compacted and marginated within the nucleus. We tested the role of EBV lytic DNA amplification ... -
Development of TOXGFP Assay to Measure Transmembrane Interactions
(2015)Association of transmembrane alpha-helices is a fundamental part of membrane protein structure. The development of an assay (TOXGFP) allows for the efficient study of transmembrane helix oligomerization in live cells. The ... -
The effect of neuropeptides on growth and function of bovine articular chondrocytes
(2007)Cartilage injury is a central issue in orthopedics to which there is no known physiological treatment. Neuropeptides playa role in the proliferative and reparative processes of many tissue types, but little is known about ... -
The Effects of Doa4 and Other Multivesicular-Body Proteins on Brome Mosaic Virus Replication in Yeast
(2008)Brome Mosaic Virus (BMV) replication was measured in yeast single and double deletion mutants of Doa4 and other proteins in the multivesicular-body (MVB) pathway in order to determine the role of Doa4 and other MVB proteins ...