Effects of Bupropion and Naltrexone on the Discriminative Stimulus Effects Produced by 22 Hours Food Deprivation
Barlow, Molly A.
Vanden Avond, Mark A.
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Bupropion inhibits dopamine and norepinephrine transporters and is clinically used to treat depression and as a smoking cessation aid. Naltrexone is an opioid antagonist and is clinically used to treat opioid and alcohol dependence. Studies show that bupropion decreases food intake in rats (Zarrindast, Hosseini-Nia, 1988). Naltrexone has also been shown to decrease food intake in rats (Kirkham, Blundell, 1987). Bupropion in combination with naltrexone decreases food intake in rats (Clapper, Athanacio, Wittmer, Griffin, D'Souza, Parkes, & Roth, 2013). The purpose of this study was to examine the effects of bupropion, naltrexone, and combinations of bupropion and naltrexone in non-restricted rats trained to discriminate between 22- and 2-hr food deprivation to gain better understanding of neurochemicals mediating the discriminative stimulus e ects of 22-hr food deprivation.
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