Synthesis of Deuterated, Protected Amino Acids Tyrosine and Serine

Abstract

In the United States, 1 in every 8 women will be diagnosed with breast cancer at some point in their lives. Although adjuvant therapies have improved therapy success after lumpectomy or mastectomy, therapeutic choices are made without adequate information to predict efficiency or effectiveness of the treatment. Due to weak or inappropriate therapy choice, additional pressure and strain is placed on cells. The purpose of this study was to establish the first steps towards a standardized multiplex quantification of kinase activity in a breast cancer model through surface enhanced Raman spectroscopy (SERS) paired with peptide functionalized nanoparticle based biosensors. By establishing this multiplex quantification, adjuvant therapies will become more effective and personalized for individuals with breast cancer.