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FCGR3A Variability: Copy Number, Single Nucleotide Polymorphisms, and Efficacy of immunotherapy
(2017-05-15)
In order to develop personalized immunotherapies for diseases like cancer, a key
component is to understand the profiles of specific genes that may influence the response
to treatment. For example, genes like the Fc gamma ...
Measuring mitochondrial nonenyzmatic lysine acetylation
(2017-05-15)
Protein acetylation is a regulatory modification affecting numerous biochemical and cellular processes. Over half of the proteins in mitochondria have been identified as acetylated, however mechanism of acetylation has not ...
Quantification of interneurons present in postmortem adult Down syndrome Brain
(2017-06-13)
Neuroanatomical abnormalities in the DS brain contribute to specific cognitive deficits in DS individuals. Histopathology has consistently revealed fewer neurons in the DS cerebral cortex. Based on neuron morphology and ...
The potential functional consequences of mandible shape evolution in giant house mice from Gough Island
(2017-06-13)
An extremely large-bodied Mus musculus domesticus mouse population from the remote Gough Island (GI) were used to study how the evolution of shape may affect the performance of a morphological trait. The study question ...
Nurr1 knockout in substantia nigra proposed to result in cognitive deficits in Rattus norvegicus
(2017-06-13)
Many Parkinson's disease (PD) patients suffer from cognitive impairment. Reduced secretion of dopamine (DA) from substantia nigra (SN) to striatum results in motor deficits in PD patients, but little is known about its ...