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Reduction of androgen induced reactive oxygen species (ROS) production as a method of preventing prostate cancer
(2007)
Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ...
The Identification and Characterization of Cytoplasmic Acetylated Lysines
(2011)
Lysine acetylation by histone acetyl transferascs (HATs) is a reversible posttranscriptional
modification that plays a key role in regulating several biological processes, such as the cell cycle, nuclear transport, and ...
The Biochemical Characterization of a Translational Repressor
(2008)
Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ...
To determine the functional relevance of circadian Fabp7 expression in memory consolidation
(2007)
Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ...
Transgenic zebrafish that carry inducible zic2a fusion proteins
(2007)
Zic genes encode proteins that contain zinc fingers used to bind DNA and modify transcription of target genes. Several zic genes have been identified that are critical in regulating nervous system development in a wide ...
Evaluating the effects of a possible therapeutic drug for Rett Syndrome in a mouse model
(2010)
Rett Syndrome (RTT) is a neurodevelopmental disorder that affects girls with an estimated prevalence of 1 in 10,000-15,000, with no current cure or effective treatment. Most RTT cases are caused by human methyl-CpG binding ...
Going from embryo to adult: How zebrafish zic genes are regulated during development
(2009)
This project aims to further our understanding of developmental genetics by identifying unknown transcription factor binding sites that play an important role in regulating zic2a, a gene required for proper neural development ...
Identification Of Acetylated Lysine Residues On The ER Chaperone BiP
(2011)
Alzheimer's disease (AD) pathogenesis involves the abnormal production of a small peptide
called Abeta. The rate-limiting enzyme for the generation of Abeta is BACEl and, as such, its downregulation decreases Abeta levels. ...
An investigation on the effects of mutations in the ATG12 autophagy pathway of Arabidopsis thaliana
(2007)
Under nutrient-deficient conditions, plants are forced to recycle secondary cellular constituents to conserve energy for the more essential processes (Klionsky, et al. 2000). Plants accomplish this through a process called ...
A ts-paralytic neurodegeneration mutant in Drosophila reveals differential requirement for the glycolytic gene Aldolase in neurons and glia
(2011)
Several neurodegenerative diseases, such as Parkinson's disease, amyotrophic lateral
sclerosis, and Alzheimer's disease have been linked to metabolic disruption in neurons.
This suggests that neurons are particularly ...