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Investigating the Role of SDHB in Cardiac Regeneration
(2023)
Heart failure is the leading cause of death in the United States. The long wait for heart
transplants and the risk of graft rejection has motivated heart regeneration research to advance
heart failure treatment. Importantly, ...
Investigation of the role of CarD in transcription initiation and the stringent response in Zymomonas mobilis
(2023)
In some prokaryotes, transcriptional regulator CarD stabilizes the open promoter complex
during transcription initiation. As both a transcriptional activator and repressor, CarD can be
used to coordinate gene expression ...
α7-Nicotinic Acetylcholine Receptor Signaling in Cardiac Regeneration
(2020-05)
Heart disease is the leading cause of death in the U.S. Loss of heart regenerative capacity in adult mammals is a principle reason why adults fail to recover from heart diseases. In contrast, neonatal mammals possess ...
Single Nuclei RNA Sequencing of Mice Hippocampus to Evaluate in vivo Gene Editing by a Biodegradable Nanocage for CRISPR/Cas9 Ribonucleoproteins
(2021)
In recent years, CRISPR-Cas9 technology has shown promise as a versatile gene editing
tool that enables precise nucleotide base-editing (Sander & Joung, 2014), and are anticipated to
drive the next wave of gene therapies ...
Genes, Neonatal Nursery and Biobehavioral Development
(2022)
Evidence suggests that early life stress (ELS) has significant impacts on development and health. Neonatal intensive care unit (NICU) placement may be a form of ELS. Better understanding of the consequences and risk factors ...
Reduction of androgen induced reactive oxygen species (ROS) production as a method of preventing prostate cancer
(2007)
Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ...
The Identification and Characterization of Cytoplasmic Acetylated Lysines
(2011)
Lysine acetylation by histone acetyl transferascs (HATs) is a reversible posttranscriptional
modification that plays a key role in regulating several biological processes, such as the cell cycle, nuclear transport, and ...
The Biochemical Characterization of a Translational Repressor
(2008)
Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ...
To determine the functional relevance of circadian Fabp7 expression in memory consolidation
(2007)
Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ...