Heart failure is the leading cause of death in the United States. The long wait for heart transplants and the risk of graft rejection has motivated heart regeneration research to advance heart failure treatment. Importantly, ...

In some prokaryotes, transcriptional regulator CarD stabilizes the open promoter complex during transcription initiation. As both a transcriptional activator and repressor, CarD can be used to coordinate gene expression ...

Heart disease is the leading cause of death in the U.S. Loss of heart regenerative capacity in adult mammals is a principle reason why adults fail to recover from heart diseases. In contrast, neonatal mammals possess ...

In recent years, CRISPR-Cas9 technology has shown promise as a versatile gene editing tool that enables precise nucleotide base-editing (Sander & Joung, 2014), and are anticipated to drive the next wave of gene therapies ...

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Evidence suggests that early life stress (ELS) has significant impacts on development and health. Neonatal intensive care unit (NICU) placement may be a form of ELS. Better understanding of the consequences and risk factors ...