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Reduction of androgen induced reactive oxygen species (ROS) production as a method of preventing prostate cancer
(2007)
Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ...
The Biochemical Characterization of a Translational Repressor
(2008)
Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ...
To determine the functional relevance of circadian Fabp7 expression in memory consolidation
(2007)
Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ...
Transgenic zebrafish that carry inducible zic2a fusion proteins
(2007)
Zic genes encode proteins that contain zinc fingers used to bind DNA and modify transcription of target genes. Several zic genes have been identified that are critical in regulating nervous system development in a wide ...
Going from embryo to adult: How zebrafish zic genes are regulated during development
(2009)
This project aims to further our understanding of developmental genetics by identifying unknown transcription factor binding sites that play an important role in regulating zic2a, a gene required for proper neural development ...
An investigation on the effects of mutations in the ATG12 autophagy pathway of Arabidopsis thaliana
(2007)
Under nutrient-deficient conditions, plants are forced to recycle secondary cellular constituents to conserve energy for the more essential processes (Klionsky, et al. 2000). Plants accomplish this through a process called ...
Characterization of my18, a mutant exhibiting abnormal expression of the C. elegans polycystic kidney disease gene
(2007)
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder affecting 1/400 to 1/800 individuals in the population. Mutations in the human genes PKD1 and PKD2, which encode Polycystin-l (PC-I) and ...
Characterization of nuclear RNAi defective mutants in C. elegans
(2008)
Proper gene expression is crucial for all cellular processes, and changes in normal gene expression has been implicated in a number of human diseases, including asthma, heart disease, and cancer (Guajardo 2005, Tan 2002, ...
Pilot screen for second site suppressors of wstd
(2009)
Triosephosphate isomerase (TPI) loss of function (wstd), in flies has been shown to have increases in methylglyoxal and advanced glycation end products (AGEs) which have also been found in increased levels in diseases ...
The role of a soluble, competitive FGF receptor in embryonic stem cell-derived hematopoiesis
(2007)
The fibroblast growth factor (FGF) signaling pathway plays a pivotal role in the maintenance of embryonic stem cells (ESCs) as well as their differentiation into the hematopoietic lineage. We observed that supplementing ...