Browsing Genetics Honors Theses and Research Papers by Title
Now showing items 1-20 of 37
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Activation and suppression of macrophages: implications for cancer immunotherapy
(2006)It is widely known that macrophages can be activated to kill tumor cells. It is also known that tumor-infiltrating macrophages can be immunosuppressed. The mechanisms of both tumor killing by activated macrophages and ... -
The Biochemical Characterization of a Translational Repressor
(2008)Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ... -
Characterization of my18, a mutant exhibiting abnormal expression of the C. elegans polycystic kidney disease gene
(2007)Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder affecting 1/400 to 1/800 individuals in the population. Mutations in the human genes PKD1 and PKD2, which encode Polycystin-l (PC-I) and ... -
Characterization of nuclear RNAi defective mutants in C. elegans
(2008)Proper gene expression is crucial for all cellular processes, and changes in normal gene expression has been implicated in a number of human diseases, including asthma, heart disease, and cancer (Guajardo 2005, Tan 2002, ... -
The effects of the Anopheles gambiae CLIPC3 and CLIPC1 genes on melanization of an abiotic target
(2007)Melanization is a mechanism of innate immunity in arthropods wherein a thick capsule of melanin is formed around foreign objects. Little is known about this pathway biochemically though serine proteases are known to ... -
Evaluating the effects of a possible therapeutic drug for Rett Syndrome in a mouse model
(2010)Rett Syndrome (RTT) is a neurodevelopmental disorder that affects girls with an estimated prevalence of 1 in 10,000-15,000, with no current cure or effective treatment. Most RTT cases are caused by human methyl-CpG binding ... -
FCGR3A Variability: Copy Number, Single Nucleotide Polymorphisms, and Efficacy of immunotherapy
(2017-05-15)In order to develop personalized immunotherapies for diseases like cancer, a key component is to understand the profiles of specific genes that may influence the response to treatment. For example, genes like the Fc gamma ... -
Female California mouse scent marking behavior and its implications for the pair bond
(2013)Scent marking has been shown to be an active form of communication for male mice in claiming territory, advertising for females, and mate guarding. Yet little is known about how females use scent marking behaviorally. ... -
Genes, Neonatal Nursery and Biobehavioral Development
(2022)Evidence suggests that early life stress (ELS) has significant impacts on development and health. Neonatal intensive care unit (NICU) placement may be a form of ELS. Better understanding of the consequences and risk factors ... -
A genetic approach to understanding co-regulated MAPK genes in Arabidopsis thaliana
(2007)Mitogen-activated protein kinase (MAPK) signaling cascades connect cellular signal and gene transcription in cells. The pathway can regulate cell division, cell growth, and other pathways in eukaryotes. We used the ... -
Going from embryo to adult: How zebrafish zic genes are regulated during development
(2009)This project aims to further our understanding of developmental genetics by identifying unknown transcription factor binding sites that play an important role in regulating zic2a, a gene required for proper neural development ... -
Haplotype frequencies at the miR156 and miR172 transcript regions show a significant response to divergent recurrent selection for vegetative phase change in maize
(2009)Sweet corn (Zea mays L). plants that transition from juvenility to the adult phase earlier during development are generally more resistant to common rust (Puccinia sorghi), a disease that causes substantial yield loss in ... -
The Identification and Characterization of Cytoplasmic Acetylated Lysines
(2011)Lysine acetylation by histone acetyl transferascs (HATs) is a reversible posttranscriptional modification that plays a key role in regulating several biological processes, such as the cell cycle, nuclear transport, and ... -
Identification Of Acetylated Lysine Residues On The ER Chaperone BiP
(2011)Alzheimer's disease (AD) pathogenesis involves the abnormal production of a small peptide called Abeta. The rate-limiting enzyme for the generation of Abeta is BACEl and, as such, its downregulation decreases Abeta levels. ... -
Identification of QTLs for voluntary running activity in mice for the CBA/J and DBA/2J mouse strains
(2009)Our goal is to understand the genetic factors related to voluntary running activity. Voluntary running activity in humans and mice is known to be a heritable behavioral trait. The genetic factors influencing voluntary ... -
Investigating the Role of SDHB in Cardiac Regeneration
(2023)Heart failure is the leading cause of death in the United States. The long wait for heart transplants and the risk of graft rejection has motivated heart regeneration research to advance heart failure treatment. Importantly, ... -
Investigation of the role of CarD in transcription initiation and the stringent response in Zymomonas mobilis
(2023)In some prokaryotes, transcriptional regulator CarD stabilizes the open promoter complex during transcription initiation. As both a transcriptional activator and repressor, CarD can be used to coordinate gene expression ... -
An investigation on the effects of mutations in the ATG12 autophagy pathway of Arabidopsis thaliana
(2007)Under nutrient-deficient conditions, plants are forced to recycle secondary cellular constituents to conserve energy for the more essential processes (Klionsky, et al. 2000). Plants accomplish this through a process called ... -
Measuring mitochondrial nonenyzmatic lysine acetylation
(2017-05-15)Protein acetylation is a regulatory modification affecting numerous biochemical and cellular processes. Over half of the proteins in mitochondria have been identified as acetylated, however mechanism of acetylation has not ... -
Nurr1 knockout in substantia nigra proposed to result in cognitive deficits in Rattus norvegicus
(2017-06-13)Many Parkinson's disease (PD) patients suffer from cognitive impairment. Reduced secretion of dopamine (DA) from substantia nigra (SN) to striatum results in motor deficits in PD patients, but little is known about its ...