Browsing Genetics Honors Theses and Research Papers by Issue Date
Now showing items 1-20 of 37
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Activation and suppression of macrophages: implications for cancer immunotherapy
(2006)It is widely known that macrophages can be activated to kill tumor cells. It is also known that tumor-infiltrating macrophages can be immunosuppressed. The mechanisms of both tumor killing by activated macrophages and ... -
Reduction of androgen induced reactive oxygen species (ROS) production as a method of preventing prostate cancer
(2007)Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ... -
To determine the functional relevance of circadian Fabp7 expression in memory consolidation
(2007)Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ... -
Transgenic zebrafish that carry inducible zic2a fusion proteins
(2007)Zic genes encode proteins that contain zinc fingers used to bind DNA and modify transcription of target genes. Several zic genes have been identified that are critical in regulating nervous system development in a wide ... -
An investigation on the effects of mutations in the ATG12 autophagy pathway of Arabidopsis thaliana
(2007)Under nutrient-deficient conditions, plants are forced to recycle secondary cellular constituents to conserve energy for the more essential processes (Klionsky, et al. 2000). Plants accomplish this through a process called ... -
Characterization of my18, a mutant exhibiting abnormal expression of the C. elegans polycystic kidney disease gene
(2007)Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder affecting 1/400 to 1/800 individuals in the population. Mutations in the human genes PKD1 and PKD2, which encode Polycystin-l (PC-I) and ... -
The role of a soluble, competitive FGF receptor in embryonic stem cell-derived hematopoiesis
(2007)The fibroblast growth factor (FGF) signaling pathway plays a pivotal role in the maintenance of embryonic stem cells (ESCs) as well as their differentiation into the hematopoietic lineage. We observed that supplementing ... -
The effects of the Anopheles gambiae CLIPC3 and CLIPC1 genes on melanization of an abiotic target
(2007)Melanization is a mechanism of innate immunity in arthropods wherein a thick capsule of melanin is formed around foreign objects. Little is known about this pathway biochemically though serine proteases are known to ... -
A genetic approach to understanding co-regulated MAPK genes in Arabidopsis thaliana
(2007)Mitogen-activated protein kinase (MAPK) signaling cascades connect cellular signal and gene transcription in cells. The pathway can regulate cell division, cell growth, and other pathways in eukaryotes. We used the ... -
Starvation responses of invasive and non-invasive Eurytemora affinis populations
(2007)Within the past century, the copepod Eurytemora affinis have invaded freshwater from saline sources throughout the Northern Hemisphere. Two genetically divergent clades (Atlantic and North Atlantic) of E. affinis coexist ... -
The Biochemical Characterization of a Translational Repressor
(2008)Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ... -
Characterization of nuclear RNAi defective mutants in C. elegans
(2008)Proper gene expression is crucial for all cellular processes, and changes in normal gene expression has been implicated in a number of human diseases, including asthma, heart disease, and cancer (Guajardo 2005, Tan 2002, ... -
The role of dynamin and Rho1 during cytokinesis in C. elegans
(2008)Cytokinesis is the final phase of cell division in which a single cell is physically separated into two daughter cells. This is accomplished by constricting the acto-myosin contractile ring and inserting new membrane along ... -
Going from embryo to adult: How zebrafish zic genes are regulated during development
(2009)This project aims to further our understanding of developmental genetics by identifying unknown transcription factor binding sites that play an important role in regulating zic2a, a gene required for proper neural development ... -
Pilot screen for second site suppressors of wstd
(2009)Triosephosphate isomerase (TPI) loss of function (wstd), in flies has been shown to have increases in methylglyoxal and advanced glycation end products (AGEs) which have also been found in increased levels in diseases ... -
Preneoplastic Lesion Growth in B6.Hcs7C3H 219R8 Congenic Hepatocarcinogen-Sensitive Mus musculus
(2009)A region of mouse Chromosome 1, called the Hcs7 locus, is involved in the susceptibility to liver carcinogenesis in the inbred mouse strain, C3H/HeJ (C3H). Linkage analysis of a cross between C3H and a strain that is ... -
Identification of QTLs for voluntary running activity in mice for the CBA/J and DBA/2J mouse strains
(2009)Our goal is to understand the genetic factors related to voluntary running activity. Voluntary running activity in humans and mice is known to be a heritable behavioral trait. The genetic factors influencing voluntary ... -
Haplotype frequencies at the miR156 and miR172 transcript regions show a significant response to divergent recurrent selection for vegetative phase change in maize
(2009)Sweet corn (Zea mays L). plants that transition from juvenility to the adult phase earlier during development are generally more resistant to common rust (Puccinia sorghi), a disease that causes substantial yield loss in ... -
Semantic category learning through explicit and implicit knowledge of complex sequences
(2009)Objects with similar functions are judged to be similar "kinds of things," even when they have few directly-observable properties in common. How do people learn such "functional" similarity? One possibility is that objects ... -
Evaluating the effects of a possible therapeutic drug for Rett Syndrome in a mouse model
(2010)Rett Syndrome (RTT) is a neurodevelopmental disorder that affects girls with an estimated prevalence of 1 in 10,000-15,000, with no current cure or effective treatment. Most RTT cases are caused by human methyl-CpG binding ...