Browsing Genetics Honors Theses and Research Papers by Title
Now showing items 25-37 of 37
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Quantification of interneurons present in postmortem adult Down syndrome Brain
(2017-06-13)Neuroanatomical abnormalities in the DS brain contribute to specific cognitive deficits in DS individuals. Histopathology has consistently revealed fewer neurons in the DS cerebral cortex. Based on neuron morphology and ... -
Reduction of androgen induced reactive oxygen species (ROS) production as a method of preventing prostate cancer
(2007)Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ... -
A role for FoxQ-1 in memory and learning
(2010)Using a genome-wide screen, genes that were differentially expressed between aged rats that were able to learn a spatial task (aged superior learners: SL), and learning-impaired rates (AI) were identified in the CA1 region ... -
The role of a soluble, competitive FGF receptor in embryonic stem cell-derived hematopoiesis
(2007)The fibroblast growth factor (FGF) signaling pathway plays a pivotal role in the maintenance of embryonic stem cells (ESCs) as well as their differentiation into the hematopoietic lineage. We observed that supplementing ... -
The role of dynamin and Rho1 during cytokinesis in C. elegans
(2008)Cytokinesis is the final phase of cell division in which a single cell is physically separated into two daughter cells. This is accomplished by constricting the acto-myosin contractile ring and inserting new membrane along ... -
Semantic category learning through explicit and implicit knowledge of complex sequences
(2009)Objects with similar functions are judged to be similar "kinds of things," even when they have few directly-observable properties in common. How do people learn such "functional" similarity? One possibility is that objects ... -
Single Nuclei RNA Sequencing of Mice Hippocampus to Evaluate in vivo Gene Editing by a Biodegradable Nanocage for CRISPR/Cas9 Ribonucleoproteins
(2021)In recent years, CRISPR-Cas9 technology has shown promise as a versatile gene editing tool that enables precise nucleotide base-editing (Sander & Joung, 2014), and are anticipated to drive the next wave of gene therapies ... -
Starvation responses of invasive and non-invasive Eurytemora affinis populations
(2007)Within the past century, the copepod Eurytemora affinis have invaded freshwater from saline sources throughout the Northern Hemisphere. Two genetically divergent clades (Atlantic and North Atlantic) of E. affinis coexist ... -
To determine the functional relevance of circadian Fabp7 expression in memory consolidation
(2007)Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ... -
Transgenic zebrafish that carry inducible zic2a fusion proteins
(2007)Zic genes encode proteins that contain zinc fingers used to bind DNA and modify transcription of target genes. Several zic genes have been identified that are critical in regulating nervous system development in a wide ... -
Transmission ratio distortion in the hybrid offspring of three mouse subspecies
(2010)A crucial component of understanding the origin or new species is understanding how reproductive isolation evolves between divergent populations. The relative importance of Dobzhansky-Muller incompatibilities as compared ... -
A ts-paralytic neurodegeneration mutant in Drosophila reveals differential requirement for the glycolytic gene Aldolase in neurons and glia
(2011)Several neurodegenerative diseases, such as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease have been linked to metabolic disruption in neurons. This suggests that neurons are particularly ... -
α7-Nicotinic Acetylcholine Receptor Signaling in Cardiac Regeneration
(2020-05)Heart disease is the leading cause of death in the U.S. Loss of heart regenerative capacity in adult mammals is a principle reason why adults fail to recover from heart diseases. In contrast, neonatal mammals possess ...