Browsing Genetics Honors Theses and Research Papers by Title
Now showing items 19-37 of 37
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Measuring mitochondrial nonenyzmatic lysine acetylation
(2017-05-15)Protein acetylation is a regulatory modification affecting numerous biochemical and cellular processes. Over half of the proteins in mitochondria have been identified as acetylated, however mechanism of acetylation has not ... -
Nurr1 knockout in substantia nigra proposed to result in cognitive deficits in Rattus norvegicus
(2017-06-13)Many Parkinson's disease (PD) patients suffer from cognitive impairment. Reduced secretion of dopamine (DA) from substantia nigra (SN) to striatum results in motor deficits in PD patients, but little is known about its ... -
Pilot screen for second site suppressors of wstd
(2009)Triosephosphate isomerase (TPI) loss of function (wstd), in flies has been shown to have increases in methylglyoxal and advanced glycation end products (AGEs) which have also been found in increased levels in diseases ... -
The potential functional consequences of mandible shape evolution in giant house mice from Gough Island
(2017-06-13)An extremely large-bodied Mus musculus domesticus mouse population from the remote Gough Island (GI) were used to study how the evolution of shape may affect the performance of a morphological trait. The study question ... -
Preneoplastic Lesion Growth in B6.Hcs7C3H 219R8 Congenic Hepatocarcinogen-Sensitive Mus musculus
(2009)A region of mouse Chromosome 1, called the Hcs7 locus, is involved in the susceptibility to liver carcinogenesis in the inbred mouse strain, C3H/HeJ (C3H). Linkage analysis of a cross between C3H and a strain that is ... -
The PrkA phosphosubstrate GpsB in Listeria monocytogenes promotes cell wall stress responses
(2021)None provided -
Quantification of interneurons present in postmortem adult Down syndrome Brain
(2017-06-13)Neuroanatomical abnormalities in the DS brain contribute to specific cognitive deficits in DS individuals. Histopathology has consistently revealed fewer neurons in the DS cerebral cortex. Based on neuron morphology and ... -
Reduction of androgen induced reactive oxygen species (ROS) production as a method of preventing prostate cancer
(2007)Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ... -
A role for FoxQ-1 in memory and learning
(2010)Using a genome-wide screen, genes that were differentially expressed between aged rats that were able to learn a spatial task (aged superior learners: SL), and learning-impaired rates (AI) were identified in the CA1 region ... -
The role of a soluble, competitive FGF receptor in embryonic stem cell-derived hematopoiesis
(2007)The fibroblast growth factor (FGF) signaling pathway plays a pivotal role in the maintenance of embryonic stem cells (ESCs) as well as their differentiation into the hematopoietic lineage. We observed that supplementing ... -
The role of dynamin and Rho1 during cytokinesis in C. elegans
(2008)Cytokinesis is the final phase of cell division in which a single cell is physically separated into two daughter cells. This is accomplished by constricting the acto-myosin contractile ring and inserting new membrane along ... -
Semantic category learning through explicit and implicit knowledge of complex sequences
(2009)Objects with similar functions are judged to be similar "kinds of things," even when they have few directly-observable properties in common. How do people learn such "functional" similarity? One possibility is that objects ... -
Single Nuclei RNA Sequencing of Mice Hippocampus to Evaluate in vivo Gene Editing by a Biodegradable Nanocage for CRISPR/Cas9 Ribonucleoproteins
(2021)In recent years, CRISPR-Cas9 technology has shown promise as a versatile gene editing tool that enables precise nucleotide base-editing (Sander & Joung, 2014), and are anticipated to drive the next wave of gene therapies ... -
Starvation responses of invasive and non-invasive Eurytemora affinis populations
(2007)Within the past century, the copepod Eurytemora affinis have invaded freshwater from saline sources throughout the Northern Hemisphere. Two genetically divergent clades (Atlantic and North Atlantic) of E. affinis coexist ... -
To determine the functional relevance of circadian Fabp7 expression in memory consolidation
(2007)Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ... -
Transgenic zebrafish that carry inducible zic2a fusion proteins
(2007)Zic genes encode proteins that contain zinc fingers used to bind DNA and modify transcription of target genes. Several zic genes have been identified that are critical in regulating nervous system development in a wide ... -
Transmission ratio distortion in the hybrid offspring of three mouse subspecies
(2010)A crucial component of understanding the origin or new species is understanding how reproductive isolation evolves between divergent populations. The relative importance of Dobzhansky-Muller incompatibilities as compared ... -
A ts-paralytic neurodegeneration mutant in Drosophila reveals differential requirement for the glycolytic gene Aldolase in neurons and glia
(2011)Several neurodegenerative diseases, such as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease have been linked to metabolic disruption in neurons. This suggests that neurons are particularly ... -
α7-Nicotinic Acetylcholine Receptor Signaling in Cardiac Regeneration
(2020-05)Heart disease is the leading cause of death in the U.S. Loss of heart regenerative capacity in adult mammals is a principle reason why adults fail to recover from heart diseases. In contrast, neonatal mammals possess ...