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An investigation on the effects of mutations in the ATG12 autophagy pathway of Arabidopsis thaliana
(2007)
Under nutrient-deficient conditions, plants are forced to recycle secondary cellular constituents to conserve energy for the more essential processes (Klionsky, et al. 2000). Plants accomplish this through a process called ...
Characterization of my18, a mutant exhibiting abnormal expression of the C. elegans polycystic kidney disease gene
(2007)
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder affecting 1/400 to 1/800 individuals in the population. Mutations in the human genes PKD1 and PKD2, which encode Polycystin-l (PC-I) and ...
Characterization of nuclear RNAi defective mutants in C. elegans
(2008)
Proper gene expression is crucial for all cellular processes, and changes in normal gene expression has been implicated in a number of human diseases, including asthma, heart disease, and cancer (Guajardo 2005, Tan 2002, ...
Pilot screen for second site suppressors of wstd
(2009)
Triosephosphate isomerase (TPI) loss of function (wstd), in flies has been shown to have increases in methylglyoxal and advanced glycation end products (AGEs) which have also been found in increased levels in diseases ...
Pre-steady state product formation rates for mutant and wild type toluene 4-monooxygenases
(2008)
This study measures the pre-steady state product formation rate for toluene 4-monooxygenase (T4MO). T4MO catalyzes the NADH and O2 dependent hydroxylation of toluene to form p-cresol. By using alternative substrates with ...
Efficiency of dietary calcium use for skeletal growth and mineralization in young pigs fed diets with various phosphorus concentrations
(2007)
Nutrient efficiencies are generally greater for animals fed diets with marginal deficiencies. In a preliminary study, however, Ca efficiency was lower in pigs fed diets with a marginal Ca deficiency (J Bone Miner Re 20:S193). ...
Effects of white yolk concentration on maturation, fertilization, and blastocyst development of bovine embryos produced in vitro
(2004)
Most in vitro embryo production (IVP) systems use some form of bovine sera in media. The most commonly used sera in maturation of bovine oocytes is fetal calf serum. A potential problem arising from this practice is ...
Optimization of recombinant E. coli protein expression in growth medium
(2007)
With the onset of novel genomic sequence data, much effort is now being taken to discover the role of many genes and the corresponding proteins that remain unknown. One of the limiting steps in such efforts has been the ...
Probing the chemistry in the active site of P4H
(2009)
Prolyl 4-hydroxylase (P4H), a mononuclear, non-heme FeII, 2-oxoglutarate and O2 dependent enzyme, plays an integral role in the biosynthesis of collagen. It catalyzes the post-translational hydroxylation of proline residues ...
Polyamide-chlorambucil conjugates
(2008)
Polyamides are chemically engineered molecules made up of sequences of pyrolle and imidazole rings. In particular sequences, these molecules have been shown to have a very high affinity and specificity for nucleic acids, ...