Prolyl 4-hydroxylase (P4H), a mononuclear, non-heme FeII, 2-oxoglutarate and O2 dependent enzyme, plays an integral role in the biosynthesis of collagen. It catalyzes the post-translational hydroxylation of proline residues ...

Polyamides are chemically engineered molecules made up of sequences of pyrolle and imidazole rings. In particular sequences, these molecules have been shown to have a very high affinity and specificity for nucleic acids, ...

In January 2006, I worked with Community Based Integrated Nutrition (COBIN) to perform water quality testing and design & distribute health questionnaires to 40 households in the Lyantonde and Kiruhura districts of rural ...

Gene therapy techniques have emerged in recent decades as a method of combating genetic disorders. One prospective branch of gene therapy is using RNA Interference (RNAi) to regulate gene expression. RNAi employs small ...

Latent infection of Epstein-Barr virus (EBV) is associated with many human cancers. Induction of lytic replication of EBV may lead to destruction of these tumor cells. The viral immediate-early gene, BZLF1, plays a key ...

There has recently been increased interest in the use of cynomolgus macaques for the study of infectious diseases. However, little focus has been given to studying the immunogenetics of these animals. To improve researcher’s ...

CB2000 is a strain of Escherichia coli (E. coli) that is extremely resistant to ionizing radiation. It was derived from a colony, referred to as the founder strain, isolated from naturally occurring Escherichia coli K12 ...

Mitogen-activated protein kinase (MAPK) signaling cascades connect cellular signal and gene transcription in cells. The pathway can regulate cell division, cell growth, and other pathways in eukaryotes. We used the ...

Stearoyl-acyl carrier protein Delta9 desaturase (Delta9D) from Ricinus communis converts stearic acid into monounsaturated oleic acid and functions to maintain the lipid composition of the cell membrane. While the desaturase ...