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Functional differences between the yeast Hsp70 molecular chaperones Ssbl and Ssb2
(2011)
Protein folding is a complex process that is mediated in the cell by molecular chaperones.
Errors in protein folding can lead to aggregation of rnisfolded proteins, causing diseases
such as Alzheimer's disease and ...
The effects of 1,25 D3 on the mouse osteopontin promoter
(2007)
Vitamin D (1,25 D3) is an important transcriptional regulator of many genes including our gene of interest, osteopontin. Osteopontin is a known regulator of bone calcification and mineralization and is involved in signaling ...
Translational regulation using the PUF scaffold and deadenylases
(2010)
Translation is a key point of regulation in gene expression. A number of regulatory proteins involved in the processes of activation and repression have been characterized through tethered function assays. We designed ...
Chronic and acute seizure activity affects NKCC1 and KCC2 expression and alters GABA-induced inhibition in the adult and developing hippocampus
(2008)
Temporal lobe epilepsy is a relatively common nervous system disorder characterized by abnormal activity in the hippocampus, often caused by a decrease in GABA inhibition. GABAA receptors are Cl- ion channels whose effects ...
Characterization of Tau Phosphorylation During the Differentiation of Human Embryonic Stem Cells
(2008)
Alzheimer's disease is the seventh leading cause of death in the United States with an estimated cost of 100 billion dollars. The severity of this neurodegenerative disease is strongly correlated with the number of ...
Mutations in CNGC2 in Arabidopsis thaliana lead to a reduction in fertility due to a sporophytic defect
(2008)
While cyclic nucleotide gated channels (CNGCs) are known to play an important role in sensory transduction in animals, little is known about their functions and the mechanisms by which they act in plants. cngc2 plants ...
Synthesis and Characterization of Gamma-Peptide Foldamers
(2011)
Elucidating folding properties of unnatural amino acids has enabled the start of function-directed design. Two types of gamma-amino acids are probed for their abilities to fold into helical secondary structure. Both ...
Large scale production of stable hemolymph juvenile hormone binding protein
(2009)
To better understand the pathways of the insect juvenile hormone (JH) action, milligram amounts of pure hemolymph juvenile hormone binding protein (hJHBP) are required. Hence the goal of this study is to scale up the system ...
Engineering of maltose-binding protein to employ a poly-arginine tag and improve protein purification
(2007)
Maltose binding protein (MBP), a solubility-enhancing fusion protein, has demonstrated great success in the application of protein purification when fused to a protein of interest. It has already been engineered to include ...
Production of Clostridium thermocellum cohesion 3 fusion proteins for cell surface docking on recombinant Saccharomyces cerevisiae
(2010)
Consolidated bioprocessing (CBP) for the production of bioethanol aims to harness engineered microbes capable of saccharifying and fermenting waste lignocellulosic biomass in one industrial step. With the goal of collaboratively ...