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The Biochemical Characterization of a Translational Repressor
(2008)
Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ...
To determine the functional relevance of circadian Fabp7 expression in memory consolidation
(2007)
Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ...
Transgenic zebrafish that carry inducible zic2a fusion proteins
(2007)
Zic genes encode proteins that contain zinc fingers used to bind DNA and modify transcription of target genes. Several zic genes have been identified that are critical in regulating nervous system development in a wide ...
Going from embryo to adult: How zebrafish zic genes are regulated during development
(2009)
This project aims to further our understanding of developmental genetics by identifying unknown transcription factor binding sites that play an important role in regulating zic2a, a gene required for proper neural development ...
Chronic and acute seizure activity affects NKCC1 and KCC2 expression and alters GABA-induced inhibition in the adult and developing hippocampus
(2008)
Temporal lobe epilepsy is a relatively common nervous system disorder characterized by abnormal activity in the hippocampus, often caused by a decrease in GABA inhibition. GABAA receptors are Cl- ion channels whose effects ...
Characterization of Tau Phosphorylation During the Differentiation of Human Embryonic Stem Cells
(2008)
Alzheimer's disease is the seventh leading cause of death in the United States with an estimated cost of 100 billion dollars. The severity of this neurodegenerative disease is strongly correlated with the number of ...
Mutations in CNGC2 in Arabidopsis thaliana lead to a reduction in fertility due to a sporophytic defect
(2008)
While cyclic nucleotide gated channels (CNGCs) are known to play an important role in sensory transduction in animals, little is known about their functions and the mechanisms by which they act in plants. cngc2 plants ...
Large scale production of stable hemolymph juvenile hormone binding protein
(2009)
To better understand the pathways of the insect juvenile hormone (JH) action, milligram amounts of pure hemolymph juvenile hormone binding protein (hJHBP) are required. Hence the goal of this study is to scale up the system ...
Delta-opioid receptor (DOR) activation prolongs respiratory motor output during oxygen-glucose deprivation (OGD) in neonatal rat spinal cord in vitro
(2007)
Severe reduction of blood flow to the brain results in oxygen-glucose deprivation (OGD) and neuronal damage. DOR activation is neuroprotective during OGD in the cerebellum and cortex, but it is not known whether DOR ...
Engineering of maltose-binding protein to employ a poly-arginine tag and improve protein purification
(2007)
Maltose binding protein (MBP), a solubility-enhancing fusion protein, has demonstrated great success in the application of protein purification when fused to a protein of interest. It has already been engineered to include ...