The aim of this study is to isolate and characterize mutant fruit flies (Drosophila melanogaster) which are defective in central processing, with the ultimate goals of! finding the genes necessary for this process to ...

Vitamin D (1,25 D3) is an important transcriptional regulator of many genes including our gene of interest, osteopontin. Osteopontin is a known regulator of bone calcification and mineralization and is involved in signaling ...

Temporal lobe epilepsy is a relatively common nervous system disorder characterized by abnormal activity in the hippocampus, often caused by a decrease in GABA inhibition. GABAA receptors are Cl- ion channels whose effects ...

Alzheimer's disease is the seventh leading cause of death in the United States with an estimated cost of 100 billion dollars. The severity of this neurodegenerative disease is strongly correlated with the number of ...

While cyclic nucleotide gated channels (CNGCs) are known to play an important role in sensory transduction in animals, little is known about their functions and the mechanisms by which they act in plants. cngc2 plants ...

To better understand the pathways of the insect juvenile hormone (JH) action, milligram amounts of pure hemolymph juvenile hormone binding protein (hJHBP) are required. Hence the goal of this study is to scale up the system ...

Maltose binding protein (MBP), a solubility-enhancing fusion protein, has demonstrated great success in the application of protein purification when fused to a protein of interest. It has already been engineered to include ...

This study measures the pre-steady state product formation rate for toluene 4-monooxygenase (T4MO). T4MO catalyzes the NADH and O2 dependent hydroxylation of toluene to form p-cresol. By using alternative substrates with ...

With the onset of novel genomic sequence data, much effort is now being taken to discover the role of many genes and the corresponding proteins that remain unknown. One of the limiting steps in such efforts has been the ...