Elucidating folding properties of unnatural amino acids has enabled the start of function-directed design. Two types of gamma-amino acids are probed for their abilities to fold into helical secondary structure. Both ...

The galactan, a polymer of galactofuranose (Galf), is a key component of the hydrophobic cell wall of Mycobacterium tuberculosis, the bacterial species that is responsible for tuberculosis. Much remains unknown about the ...

Prolyl 4-hydroxylase (P4H), a mononuclear, non-heme FeII, 2-oxoglutarate and O2 dependent enzyme, plays an integral role in the biosynthesis of collagen. It catalyzes the post-translational hydroxylation of proline residues ...