Many large- and small-scale changes occur in the genomes of tumor cells. The optical mapping system was used previously to discover structural variations (OSAs; Optical Structural Alterations) in tumor genomes. OSAs are ...

Through previous studies, it has been found that Zebrafish embryos show a predictable pattern of cell division consisting of the spindle apparatus always aligning perpendicular to its orientation in the previous cell stage. ...

Mutated SETX, a human gene encoding for the protein Senataxin, has been identified among patients with two different neurodegenerative disorders--ataxia-ocular apraxia 2 (AOA2) and amyotrophic lateral sclerosis 4 (ALS4). ...

Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ...

Lysine acetylation by histone acetyl transferascs (HATs) is a reversible posttranscriptional modification that plays a key role in regulating several biological processes, such as the cell cycle, nuclear transport, and ...

Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ...

Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ...

Zic genes encode proteins that contain zinc fingers used to bind DNA and modify transcription of target genes. Several zic genes have been identified that are critical in regulating nervous system development in a wide ...

Rett Syndrome (RTT) is a neurodevelopmental disorder that affects girls with an estimated prevalence of 1 in 10,000-15,000, with no current cure or effective treatment. Most RTT cases are caused by human methyl-CpG binding ...

This project aims to further our understanding of developmental genetics by identifying unknown transcription factor binding sites that play an important role in regulating zic2a, a gene required for proper neural development ...