Prostate cancer is a leading cause of cancer deaths among men and development of a preventative agent is urgently needed. Reactive oxygen species (ROS) are carcinogens and are linked to prostate tumor development. ROS ...

Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ...

Fatty-acid binding protein 7 (Fabp7) is closely related to sleep/wake cycle and regulated in a circadian pattern. To investigate whether the expression affects learning and memory behavior, we used the Drosophila model. ...

Zic genes encode proteins that contain zinc fingers used to bind DNA and modify transcription of target genes. Several zic genes have been identified that are critical in regulating nervous system development in a wide ...

This project aims to further our understanding of developmental genetics by identifying unknown transcription factor binding sites that play an important role in regulating zic2a, a gene required for proper neural development ...

Under nutrient-deficient conditions, plants are forced to recycle secondary cellular constituents to conserve energy for the more essential processes (Klionsky, et al. 2000). Plants accomplish this through a process called ...

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder affecting 1/400 to 1/800 individuals in the population. Mutations in the human genes PKD1 and PKD2, which encode Polycystin-l (PC-I) and ...

Proper gene expression is crucial for all cellular processes, and changes in normal gene expression has been implicated in a number of human diseases, including asthma, heart disease, and cancer (Guajardo 2005, Tan 2002, ...

Triosephosphate isomerase (TPI) loss of function (wstd), in flies has been shown to have increases in methylglyoxal and advanced glycation end products (AGEs) which have also been found in increased levels in diseases ...

The fibroblast growth factor (FGF) signaling pathway plays a pivotal role in the maintenance of embryonic stem cells (ESCs) as well as their differentiation into the hematopoietic lineage. We observed that supplementing ...