Browsing College of Agricultural and Life Sciences Honors and Undergraduate Research Program by Title
Now showing items 1-20 of 200
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Activation and suppression of macrophages: implications for cancer immunotherapy
(2006)It is widely known that macrophages can be activated to kill tumor cells. It is also known that tumor-infiltrating macrophages can be immunosuppressed. The mechanisms of both tumor killing by activated macrophages and ... -
Analysis of StAR RNA Splicing and Lipid Droplets Composition in MA10 Cells Under Different Stimuli
(2023)Steroidogenic acute regulatory protein (StAR) is a transport protein which plays a key role in steroidogenesis. Different pathways can activate StAR transcription. cAMP activates PKA which phosphorylates CREB. PKA also ... -
Analyzing interactions between the GV1 Cell Line, Juvenile Hormone, and Juvenile Hormone Binding Protein
(2011)Insect juvenile hormone (JH) and its hemolymph transport protein, juvenile hormone binding protein (JHBP) play key roles in the development of many insects. However, the exact mechanism via which JH and JHBP regulates ... -
Analyzing the protective effect of foods on Salmonella enterica transmission
(2014)One of the most significant hurdles foodbome pathogens encounter is the acid barrier of the stomach. Salmonella, unlike other pathogens like E. coli 0157:H7 has a high infectious dose and is sensitive to low pH (pH 2). ... -
Angiopoietin-2 Levels increase following Oxygen Glucose Deprivation (OGD) and Reperfusion in Brain Microvascular Endothelial Cells
(2022-02)Stroke is a leading cause of death, as onset induces an innate immune response using Toll-like receptor 4 (TLR4), which promotes inflammation and blood-brain barrier (BBB) permeability. TLR4 is a receptor for high-mobility ... -
ANTITUMOR EFFECTS OF ANTl-CD40/CPG IMMUNOTHERAPY COMBINED WITH GEMCIT ABINE OR 5-FLUOROURACIL CHEMOTHERAPY IN THE B 16 MELANOMA MODEL
(2013)Our previous studies demonstrated that anti-CD40 mAb (anti-CD40) can synergize with CpG oligodeoxynucleotides (CpG) to mediate antitumor effects by activating myeloid cells such as macro phages in tumor-bearing mice. ... -
The Apoptotic Role of Cpeb1 in INS-1 Cells
(2022)The dedifferentiation of pancreatic (3-cells commonly occurs in the pathogenesis of both type 1 and type 2 diabetes. The (3-cell identity undergoes unique changes depending on the diabetogenic stress that is encountered. ... -
Attempts to analyze the RNA-binding specificity of the C. elegans RNP-8 protein
(2010)Cytoplasmic polyadenylation is a key mechanism of gene regulation in all eukaryotes. The C. elegans GLD-2 protein provides the catalytic activity for a cytoplasmic poly(A) polymerase, but GLD-2 must partner with another ... -
AXL mediates the nuclear translocation of EGFR
(2015)Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that has shown efficacy in numerous cancer types. Clinical data suggests that patients whom initially respond to cetuximab eventually acquire ... -
Bacterial Community Spatial and Temporal Variation in a North Temperate Bog Lake
(2012)Bog lakes such as Mary Lake in northern Wisconsin are ideal systems to investigate microbial communities due to easily identified spatial boundaries and well characterized seasonal ecosystem dynamics. Multiple factors are ... -
Bacterial strains within the fungus gardens of leaf-cutter ants show evidence of mutual and commensal interactions
(2017-06-13)Leaf-cutter ants have a symbiotic relationship with a fungal cultivar known as Lecuoagaricus gongylophorus. The cultivar functions as an external gut by breaking down plant polysaccharides and supplies the ants with simple ... -
Bioassay-guided purification and characterization of anti-inflammatory components in Cinnamomum burmannii
(2010)Excessive inflammatory response is implicated in many diseases such as arthritis, atherosclerosis, and cardiomyopathy. Previous studies have found that several cinnamon species could exhibit anti-inflammatory activities. ... -
The Biochemical Characterization of a Translational Repressor
(2008)Iron regulatory proteins (IRP) are crucial post-transcriptional regulators of iron metabolism. They influence the synthesis of proteins involved in iron uptake, storage and use by binding to their mRNAs. IRP1 stands out ... -
Chamber-related variation in phosphorylation state of cardiac troponin revealed by high resolution top-down mass spectrometry
(2010)Cardiac troponin complex (cTn) is a key regulator of Ca-2+- mediated cross-bridge cycling in cardiac muscle. Post-translational modifications, especially phosphorylation of cTn, are major mechanisms in modulation of ... -
Characterization of my18, a mutant exhibiting abnormal expression of the C. elegans polycystic kidney disease gene
(2007)Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disorder affecting 1/400 to 1/800 individuals in the population. Mutations in the human genes PKD1 and PKD2, which encode Polycystin-l (PC-I) and ... -
Characterization of nuclear RNAi defective mutants in C. elegans
(2008)Proper gene expression is crucial for all cellular processes, and changes in normal gene expression has been implicated in a number of human diseases, including asthma, heart disease, and cancer (Guajardo 2005, Tan 2002, ... -
Characterization of Putative RpoS-regulated Outermembrane Proteins Slp and OmpX in Escherichia coli 0157:H7
(2012)E. coli 0157:H7 is a food pathogen with exceptional tolerance to certain stressful growth conditions. RpoS is a master regulator for bacterial stress adaptation and in particular, for acid resistance genes. The role of ... -
Characterization of Tau Phosphorylation During the Differentiation of Human Embryonic Stem Cells
(2008)Alzheimer's disease is the seventh leading cause of death in the United States with an estimated cost of 100 billion dollars. The severity of this neurodegenerative disease is strongly correlated with the number of ... -
Characterization of ZIIR element of BZLF1 promoter in the context of the whole Epstein - Barr Virus genome
(2007)Latent infection of Epstein-Barr virus (EBV) is associated with many human cancers. Induction of lytic replication of EBV may lead to destruction of these tumor cells. The viral immediate-early gene, BZLF1, plays a key ... -
Characterizing the nucleotide-binding domain of Escherichia coli HscA, a specialized Hsp70 chaperone in Fe-S cluster biogenesis
(2014-05)Proteins from the ISC operon of E. coli constitute the machinery used for the synthesis of iron-sulfur clusters and their delivery to recipient apo-proteins. [2Fe-2S] cluster transfer from the holo-scaffold protein lscU ...