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dc.contributor.authorShepard, David
dc.contributor.authorLim, Jinho
dc.contributor.authorFerris, Michael
dc.description.abstractThe Gamma Knife is a highly specialized treatment unit that pro- vides an advanced stereotactic approach to the treatment of tumors, vascular malformations, and pain disorders within the head. Inside a shielded treatment unit, multiple beams of radiation are focussed into an approximately spherical volume, generating a high dose shot of ra- diation. The treatment planning process determines where to center the shots, how long to expose them for, and what size focussing hel- mets should be used, in order to cover the target with su cient dosage without overdosing normal tissue or surrounding sensitive structures. We outline a new approach that models the dose distribution nonlin- early, and uses a smoothing approach to treat discrete problem choices. The resulting nonlinear program is not convex and several heuristic ap- proaches are used to improve solution time and quality. The overall approach is fast and reliable; we give several results obtained from use in a clinical setting.en
dc.subjectnonlinear programmingen
dc.subjectGamma Knifeen
dc.titleRadiosurgery Treatment Planning via Nonlinear Programmingen
dc.typeTechnical Reporten

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  • DMI Technical Reports
    DMI Technical Reports Archive for the Department of Computer Sciences at the University of Wisconsin-Madison

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