Energetics of Hydride Transfer Reactions in Quinone Reductase 2

File(s)
Date
2012-04Author
Yang, Yer
Bartholow, Thomas G.
North, Michael A.
Advisor(s)
Hati, Sanchita
Bhattacharyay, Sudeep
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Show full item recordAbstract
Quinone Reductases belong to the class of flavin-dependent oxidoreductases. With its redox active cofactor flavin adenine dinucleotide (FAD), quinone reductases are known to utilize a ping pong kinetic mechanism during catalysis in which a hydride is swapped back and forth between flavin and its two substrates. The objectives of this study were: to explore the energetics of the ping pong kinetics in NQO2; to examine the conformational changes and free energy change due to substrate shuttling; and to determine the best functional to calculate the electron interaction.
Subject
Chemical kinetics
Quinone
Flavins
Oxidoreductases
Posters
Permanent Link
http://digital.library.wisc.edu/1793/63156Type
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Color poster with text, images, diagrams, charts, graphs, and tables.