Generation of Transcripton Factor Constructs for Mammalian Transfection

Abstract

17 B-estradiol (E2) is an ovarian steroid and regulates a number of target tissues, including the breast and uterus. The physiological effects of E2 require binding to an estrogen receptor (ER), also a transcription factor (nuclear protein). This research focuses on the mechanisms by which environmental estrogens (EEs) affect growth of cancer and pituitary cells.