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    Effect of PDE-5 inhibitors on post-exercise blood pressure

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    GehrkeJessica2010.pdf (1.764Mb)
    Date
    2010-06-14
    Author
    Gehrke, Jessica
    Advisor(s)
    Gibson, Mark
    Greany, John
    Foster, Carl
    Metadata
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    Abstract
    Blood pressure typically decreases following exercise, a phenomenon known as postexercise hypotension (PEH). The cause of PEH is unclear but may include NO dependent mechanism. Men with erectile dysfunction are prescribed PDE-5 inhibitors to prevent the destruction of NO, thus producing a vasodilatory effect. Consumption of PDE-5 inhibitors may increase the effect of PEH by augmenting the effect of NO. This study compared PEH in active middle-aged men following heavy exercise with and without presence of a PDE-5 inhibitor (Sildenafil). Physically active men (mean age 54 + 13) performed 40 minutes of heavy exercise (~80 percent MHR) on two occasions, one hour following ingestion of either 50 mg of Sildenafil or placebo. Blood pressure was measured pre-exercise and immediately post-exercise at 10 minute intervals for 40 minutes. Blood pressure was significantly lower pre-exercise on Sildenafil 108 + 14 vs. 116 + 15 and decreased in parallel throughout post-exercise. PDE-5 inhibitors apparently increase the magnitude of reduced blood pressure both before and following heavy exercise. However, there is not an augmented response of PEH on PDE-5 inhibitors.
    Subject
    Blood pressure
    Exercise -- Physiological aspects
    Phosphodiesterases -- Inhibitors
    Permanent Link
    http://digital.library.wisc.edu/1793/48324
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    • UW-L Theses & Dissertations

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