• Login
    View Item 
    •   MINDS@UW Home
    • MINDS@UW Madison
    • College of Agricultural and Life Sciences, UW-Madison
    • College of Agricultural and Life Sciences Honors and Undergraduate Research Program
    • Biology Honors Theses and Research Papers
    • View Item
    •   MINDS@UW Home
    • MINDS@UW Madison
    • College of Agricultural and Life Sciences, UW-Madison
    • College of Agricultural and Life Sciences Honors and Undergraduate Research Program
    • Biology Honors Theses and Research Papers
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    TRPV1 mediates matrix metalloproteinase expression in spinal cord injury-induced chronic neuropathic pain

    Thumbnail
    File(s)
    Abstract only (44.46Kb)
    Complete paper (archive only, not publicly available) (563.6Kb)
    Date
    2009
    Author
    Tilghman, Jessica
    Advisor(s)
    Miranpuri, Gurwattan
    Metadata
    Show full item record
    Abstract
    Neuropathic pain (NP) is common following spinal cord injury (SCI). Evidence exists for the involvement of many processes in NP development following SCI (Cain et al, 2007). Our past studies identified increased expression of nociceptive genes, including vanilloid receptor-1 (TRPV-1) following SCI in rats. Recent studies have described the matrix metalloproteases (MMPs) role in many disease processes involving the central nervous system. There is evidence that MMPs may be involved ini the pathway initiated by TRPV-1 activation. Our current study investigates the role of TRPV-1 receptor activity in the regulation of MMP-2 and following SCI. We hypothesize that 1) SCI will cause TRPV-1 upregulation and a corresponding increase in gene expression of MMP-2. The increased MMP-2 levels promote the manifestation of NP and 2) inhibition of MMP-2 by expression will attenuate NP onset. The results from our studies have potential use in the development of novel treatments for post SCI NP.
    Subject
    Neurosurgery
    Neurobiology
    Biology
    Permanent Link
    http://digital.library.wisc.edu/1793/37689
    Description
    1 p. (abstract only). YOU CANNOT OPEN THE COMPLETE PAPER. It is not available to the public, in accordance with the author's wishes.
    Part of
    • Biology Honors Theses and Research Papers

    Contact Us | Send Feedback
     

     

    Browse

    All of MINDS@UWCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Contact Us | Send Feedback