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dc.contributor.advisorWarren, Christopher
dc.contributor.advisorAnsari, Aseem
dc.contributor.authorMohandas, Appesh
dc.date.accessioned2009-10-14T17:12:26Z
dc.date.available2009-10-14T17:12:26Z
dc.date.issued2008
dc.identifier.urihttp://digital.library.wisc.edu/1793/37478
dc.description27 p.en
dc.description.abstractPolyamides are chemically engineered molecules made up of sequences of pyrolle and imidazole rings. In particular sequences, these molecules have been shown to have a very high affinity and specificity for nucleic acids, and can therefore be arranged to bind a specific sequence of DNA. By combining such a compound with a known anti-cancer agent, Chlorambucil, and using microarray technology to query the specificity and affinity with which this conjugate binds DNA, and in particular which sequences are bounden
dc.language.isoen_USen
dc.subjectBiochemistryen
dc.titlePolyamide-chlorambucil conjugatesen
dc.typeThesisen


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