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    • College of Agricultural and Life Sciences, UW-Madison
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    • Biochemistry Honors Theses and Research Papers
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    Polyamide-chlorambucil conjugates

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    2008_Mohandas.pdf (1.339Mb)
    Date
    2008
    Author
    Mohandas, Appesh
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    Abstract
    Polyamides are chemically engineered molecules made up of sequences of pyrolle and imidazole rings. In particular sequences, these molecules have been shown to have a very high affinity and specificity for nucleic acids, and can therefore be arranged to bind a specific sequence of DNA. By combining such a compound with a known anti-cancer agent, Chlorambucil, and using microarray technology to query the specificity and affinity with which this conjugate binds DNA, and in particular which sequences are bound
    Subject
    Biochemistry
    Permanent Link
    http://digital.library.wisc.edu/1793/37478
    Part of
    • Biochemistry Honors Theses and Research Papers

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