• Login
    View Item 
    •   MINDS@UW Home
    • MINDS@UW Eau Claire
    • UWEC Office of Research and Sponsored Programs
    • Student Research Day
    • View Item
    •   MINDS@UW Home
    • MINDS@UW Eau Claire
    • UWEC Office of Research and Sponsored Programs
    • Student Research Day
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Exploring Cooperative Domain Dynamics in Thermus thermophilus Leucyl-tRNA Synthetase Using Low-Frequency Normal Mode Calculations and Statistical Coupling Analysis.

    Thumbnail
    File(s)
    WeimerSpr08.pdf (1.522Mb)
    WeimerSpr08.pptx (5.123Mb)
    Date
    2009-02-11
    Author
    Weimer, Kristina
    Shane, Brianne
    Brunetto, Michael
    Advisor(s)
    Hati, Sanchita
    Bhattacharyay, Sudeep
    Metadata
    Show full item record
    Abstract
    Leucyl-tRNA synthetases are class I synthetases that catalyze the covalent attachment of leucine to the tRNAL. The three-dimensional crystal structure of Thermus thermophilus leucyl-tRNA synthetase (TtLeuRS) demonstrates a complex modular architecture where three flexible domains [the conserved connective polypeptide 1 (CP1) domain (residues 224-417), the leucine-specific (LS) domain (residues 577-634), and the zinc-1 (ZN-1) binding domain (residues 154-189)] are inserted into the central catalytic domain. In the present work, we have investigated the collective motion of various structural elements in TtLeuRS using normal mode calculations.
    Subject
    RNA
    Aminoacyl-tRNA synthetase
    Leucine
    Amino acids
    Posters
    Permanent Link
    http://digital.library.wisc.edu/1793/32284
    Description
    Color poster with text and disgrams describing research conducted by Kristina Weimer, Brianne Shane, and Michael Brunetto, advised by Sudeep Bhattacharyay and Sanchita Hati.
    Part of
    • Student Research Day

    Contact Us | Send Feedback
     

     

    Browse

    All of MINDS@UWCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Contact Us | Send Feedback