Domain-Domain Communication for tRNA Aminoacylation : Importance of Evolutionarily Conserved and Energetically Coupled Residues.
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Aminoacyl tRNA synthetases (ARSs) are an important family of protein enzymes that play a key role in protein biosynthesis. ARSs catalyze the covalent attachment of amino acids to their cognate transfer RNA (tRNA). In the present work, we investigated the molecular basis of long-range domain-domain communication in Escherichia coliprolyl-tRNA synthetase (E. coli ProRS).