Synergistic Action of 17-B Estradiol and Bisphenol A in Pituitary Cell Lines.
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The gonadal steroid 17 B-estradiol (E2) is produced primarily by the ovaries and regulates gene regulation, growth and differentiation in a number of target tissues, including the pituitary gland, where E2 regulates the production and/or release of hormones such as prolactin and luteinizing hormone. These studies examine changes in gene transcription following coadministration of E2 and a variety of E2 mimics.
Bisphenol A--Physiological effect