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dc.contributor.advisorJohnson, Stephen M.
dc.contributor.authorFreiberg, Sara M.
dc.date.accessioned2008-03-24T17:19:29Z
dc.date.available2008-03-24T17:19:29Z
dc.date.issued2007
dc.identifier.urihttp://digital.library.wisc.edu/1793/23667
dc.description2 p. (abstract and cover sheet only). YOU CANNOT OPEN THE COMPLETE PAPER. It is not available to the public, in accordance with the author’s wishesen
dc.description.abstractSevere reduction of blood flow to the brain results in oxygen-glucose deprivation (OGD) and neuronal damage. DOR activation is neuroprotective during OGD in the cerebellum and cortex, but it is not known whether DOR activation protects spinal motor circuits that contribute to breathing. To address this question, a split-bath in vitro neonatal rat brainstem/spinal cord preparation was used to record spontaneous respiratory motor output from cervical (C4-C5) and thoracic (T4-T7) ventral spinal roots. A plastic barrier at spinal segment C1 allowed oxygenated solution to continuously bathe the brainstem while the solution on the spinal cord was switched from oxygenated to OGD (0 mM glucose, bubbled with 95% nitrogen/5% carbon dioxide) with or without DADLE (1.0 uM, DOR agonist). After OGD solution was applied to the spinal cord (n=7), cervical and thoracic motor output was abolished at 25.8 ± 2.0 and 26.4 ± 1.6 min, respectively. However, when DADLE was applied 10 min prior to and during spinal OGD solution application (n=8), cervical and thoracic motor output was abolished at 41.5 ± 4.9 min (p = 0.014) and 57.0 ± 4.2 min (p = <0.001), respectively. These data suggest that spinal DOR activation protects both cervical and thoracic respiratory motor output during OGD.en
dc.format.extent193488 bytes
dc.format.extent130871 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.subjectBiologyen
dc.subjectComparative Biosciencesen
dc.titleDelta-opioid receptor (DOR) activation prolongs respiratory motor output during oxygen-glucose deprivation (OGD) in neonatal rat spinal cord in vitroen
dc.typeThesisen


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