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Synthesis of Cyclic Antigenic MUC1 Mimotopes
The immune system responds to antigens via specific sequences called epitopes. The antibody binding amino acid epitope PDTRP within the variable tandem repeat (VNTR) domain of the Mucin1 (MUC1) transmembrane epithelial ...
Synthesis and Antibody Binding Study of MUC1 Mucin Peptides with Unnatural Backbones
The MUC-1 mucin is a heavily glycosylated transmembrane protein found on the apical surface of epithelial cells with a short cytoplasmic end and a longer extracellular domain consisting of multiple 20-amino acid tandem ...
Computational Docking of Mucin Peptide Derivatives with SM3 Antibody
The crystal structure of the mucin monoclonal antibody SM3 complexed with a 13 amino acid MUC1 mucin peptide was determined. The high selectivity of the SM3 antibody to the aberrant carbohydrate cancer mucin peptide suggests ...
Synthesis of Mucin Peptide Epitopes
The MUC-1 mucin is a heavily glycosylated transmembrane protein found on the apical surface of the epithelial cells that contains a short cytoplasmic end and a long extracellular domain consisting of multiple 20-amino acid ...