Parallel combinatorial reductive amination reactions: an expedient synthesis of tertiary amines
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Describes an expedient access to N-alkylated tetrahydroisoquinolines (THIQ) by reductive alkylation reactions in the presence of Ti(OiPr)4 and NaBH4. The N-alkylated THIQs were conveniently isolated by "catch and release" purification using polymer-supported sulfonic acid (MP-TsOH) columns.
A poster containing visuals and text describing an undergraduate research project completed at the University of Wisconsin--Whitewater.