Browsing by Subject "Zebrafish"
Now showing items 1-20 of 23
-
An Assessment of BSA Protein Hydrogel Biocompatibility in the Vertebrate Intestinal Tract
(2019-08-01)The fields of biomedicine and pharmacology have a mission to design methods to treat disease while minimizing adverse side effects using novel drug delivery systems. In developing new therapeutic systems, it is crucial to ... -
Behavioral Responses of Zebrafish to Selected Chemical Constituents of the Skin
(2015-04)The purpose of this study was to develop a behavioral assay to characterize the "alarm response" in Zebrafish and to describe their behavior following exposure to chondroitin, and chemical components of cultured skin cells. ... -
Complexity and Uncertainty in Human and Ecological Risk Assessment
(2012-12-01)Multiple interacting stressors in the environment present increasingly complex risks to human health. Too often, however, the data required for traditional risk assessment are either lacking or unavailable at the necessary ... -
Effects of Global DNA Methylation Changes on Neurobehavior in Zebrafish
(2015-12-01)A number of environmental neurotoxicants modulate DNA methylation, but its influence on neurobehavior remains unclear. The laboratory has established that low-level developmental methylmercury exposure induces neurobehavioral ... -
Elucidating the Role of Spinner in Cystic Kidneys : Using a Zebrafish Model to Better Understand Polycystic Kidney Disease
(2021-04)Patients with autosomal domain polycystic kidney disease (ADPKD) suffer from disrupted kidney function due to large, fluid-filled cysts that form in the collecting ducts and kidney tubules. There is no known cure and current ... -
Ethanol Exposure Alters Motor Abilities in Zebrafish Embryos
(2021-04)Fetal Alcohol Syndrome (FAS) is a condition that can affect the physical health and behavior of developing fetuses as a result of the pregnant mother’s consumption of alcohol. FAS is found in 0.2-1.5 infants out of 1,000. ... -
Female Reproductive Impacts of Dietary Methylmercury in Yellow Perch (Perca flavescens) and Zebrafish (Danio rerio)
(2015-05-01)This study sought to evaluate the effects of dietary MeHg exposure on female teleost reproduction and phenotypically-anchor gene dysregulation in adult yellow perch (Perca flavescens) and zebrafish (Danio rerio) in order ... -
Gene Regulatory Pathways Driving Central Nervous System Regeneration in Zebrafish
(2014-12-01)Damage to the central nervous system (CNS) circuitry of adult mammals results in permanent disability. In contrast, the ability to regenerate damaged CNS nerves and achieve functional recovery occurs naturally in fish. The ... -
Laying the Groundwork for Investigating the Link Between Genes and Polycystic Kidney Disease
(2018-05)Our lab studies human polycystic kidney disease using zebrafish and C. elegans as models. Patients with autosomal dominant polycystic kidney disease (ADPKD) suffer from disrupted kidney function due to large, fluid-filled ... -
The McNair Scholars Journal, 2014
(University of Wisconsin-Superior, 2014)The McNair Program at the University of Wisconsin-Superior prepares income eligible, first generation college students and students from groups underrepresented in graduate education for doctoral study. It is a nationwide ... -
Methylene Chloride Exposure Alters Morphological Development in Zebrafish Larvae
(2021-04)The prevalence of individuals diagnosed with Autism Spectrum Disorder (ASD) has strikingly increased in recent decades. Both genetic and environmental factors have been associated with neurodevelopmental changes causing ... -
Modulation of Cholinergic Signaling in Embryonic and Larval Zebrafish: Impacts on Circadian Rhythms, Learning, and Memory
(2015-05-01)Approximately 10-20% of pregnant mothers continue to smoke during their pregnancy. Consequently, the unborn child, if it survives could suffer from low birth weight, infantile colic, impaired cognition, and sleeping problems. ... -
Neurobehavioral and Gene Expression Effects of Early Embryonic Methylmercury Exposure in Yellow Perch (Perca flavescens) and Zebrafish (Danio rerio) Larvae
(2015-08-01)Methylmercury (MeHg) is a pervasive and persistent neurotoxic environmental pollutant known to affect the behavior of fish, birds and mammals. The present study addresses the neurobehavioral and gene expression effects of ... -
Quantification of Molybdenum in Zebrafish Embryo Tissue Using Microwave Plasma Atomic Emission Spectroscopy
(2024-04)Molybdenum plays an important role in the human body as a cofactor for metabolic processes. An excess of molybdenum may lead to toxicity that causes gout-like symptoms, while too little molybdenum can be fatal. How increased ... -
Role of Non-Muscle Myosin II and Calcium in Zebrafish Midbrain-Hindbrain Boundary Morphogenesis
(2015-05-01)Elucidating the molecular mechanisms that play a role in cellular morphogenesis is critical to our understanding of brain development and function. The midbrain-hindbrain boundary (MHB) is one of the first folds in the ... -
The Role of GAP-43 Phosphorylation in Axon Behavior in the Developing Zebrafish Visual System
(2013-12-01)Developing neurons extend processes to specific targets and establish connections that are essential for future function of the nervous system. One of these processes, the axon, has a motile tip called a growth cone that ... -
THE ROLE OF NON-MUSCLE MYOSINS IN ZEBRAFISH DEVELOPMENT AND MYH9-RELATED DISEASE
(2024-08-01)The MYH genes encode highly conserved actin-based molecular motor proteins, non- muscle myosins (NMIIs), which have essential roles in cell division, cell migration, and cell shape changes. Zebrafish have two myh9 genes ... -
The Role of the Basement Membrane in Basal Tissue Folding
(2022-05-01)The ability of organs and tissues to function properly is reliant on the correct formation of shape. Proper morphogenesis is carefully regulated by both intracellular dynamics and extracellular mechanical forces. Using the ... -
The Transcription Factor Jun Is Necessary for Regeneration-associated Gene Expression During Optic Nerve Regeneration in Larval Zebrafish
(2023-08-01)The mammalian central nervous system (CNS) is incapable of regenerating damaged axons; as a result, trauma or neurodegenerative diseases such as glaucoma cause a permanent loss of function. Mature CNS neurons fail to revert ... -
Variability in Ostariophysan Fish Brain Anatomy in Relation to the Neural Pathway of Innate Fear Response
(2015-04)Our research has focused on Zebrafish (Danio rerio) and Creek Chub (Semotilus atromaculatus), two species which have distinguished applications in the inquiry of the alarm response. While Zebrafish are easily bred have a ...