Browsing by Author "M. Mahmun Hossain"
Now showing items 1-12 of 12
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Arylboronates as H2O2 or Photo-Inducible DNA Cross-Linking Agents: Design, Synthesis, Mechanism, and Anticancer Activity
Wang, Yibin (2015-12-01)Interest in the development of cancer therapies with improved selectivity and reduced host toxicity has been growing. In this thesis, we designed and synthesized a series of novel non-toxic arylboronic ester and biarylboronic ... -
Asymmetric Synthesis of All-Carbon α-aryl Quaternary Carbonyl Compounds By Palladium-catalyzed Asymmetric Allylic Alkylation (Pd-AAA) and Their Application to the Synthesis of Biologically Important 3,3′-disubstituted Oxindole and α-disubstituted Quaternary β-lactone Frameworks
Asad, Md. Sharif Al (2015-08-01)The development of catalytic, enantioselective methods for the construction of all-carbon quaternary stereocenters is an outstanding achievement in the recent history of organic chemistry. The palladium-catalyzed asymmetric ... -
Asymmetric Synthesis of Tryptophan Driviatives and Its Application to Streamlined Synthesis of Tryprosatain A and B
Huisman, Matthew (2015-05-01)Tryprostatins have been shown to be potential antitumor antimitotic agents. Tryprostatins have been isolated from the fermentation broth of marine fungal strain Aspergillus fumigatus in trace amounts. Our lab has developed ... -
Experimental Investigation of Chicken Manure Pyrolysis and Gasification
Hussein, Mohamed Hussein (2016-12-01)The dependency on renewable resources of energy in power production is a necessary step that mankind has to take if we want our advances in life and technology to resume. In a century or two, fossil fuels will be depleted, ... -
I. Palladium (0)-Catalyzed Asymmetric Rearrangement of Allyl Enol Ether for the Synthesis of Α -aryl Quaternary Carbon Center. II. Synthesis of Chiral Tryptophan Analogs and Studies Towards Synthesis of Tryprostatin A and B
Uddin, Md Nazim (2015-05-01)The development of efficient catalytic enantioselective synthesis of all carbon quaternary centers is a significant challenge in chemical synthesis due to the difficulties of carbon-carbon bond formation at quaternary ... -
I. Studies on the Organocatalytic Formation of Quaternary Stereocenters. II. Studies on the Claisen Rearrangement as a Route to Quaternary Stereocenters. III. Asymmetric Synthesis of Aldehydes Bearing Quaternary Carbon Centers via the Decarboxylative Asymmetric Allylic Alkylation
Alberch, Eduardo (2013-08-01)The asymmetric synthesis of all carbon quaternary stereocenters poses a particular challenge due to the steric congestion inherent in the formation of such centers and has been the object of intense research these last ... -
Modification of Pyrimidine and Purine Nucleotides By "Click" Chemistry: Design, Synthesis and Properties Study
Haque, Mohammad Mojibul (2014-12-01)This dissertation consists of three main parts, totaling five chapters, and focuses on developing novel nucleosides via "click" chemistry and studying their potential biological properties. Chapter three describes the ... -
Molecular Recognition in Water: Design, Synthesis, and Characterization of Rigid Molecular Receptors and Enzymatic Mechanistic Probes
Hoppe, Robert William (2016-08-01)Molecular recognition can be defined as a selective and reversible binding between two or more molecules through non-covalent interactions. Multiple weakly attractive intermolecular forces work in concert to achieve ... -
Part I: A Concise Asymmetric Synthesis of Microtubule Inhibitor Tryprostatin B Part II: Synthesis and Biological Assessment of Histone Deacetylase (HDAC) Inhibitors Part III: Acid Catalyzed Reactions of Aromatic Ketones with Ethyl Diazoacetate
Rahaman, Md Mizzanoor (2019-12-01)PART I: A CONCISE ASYMMETRIC SYNTHESIS OF MICROTUBULE INHIBITOR TRYPROSTATIN B Tryprostatin (TPS) A and B, microtubule inhibitor, are the members of a family of prenylated Trp-Pro diketopiperzine alkaloids. These two natural ... -
Part I: A Concise Synthesis of Microtubule Inhibitor Tryprostatin A and B and Its Analogs Part II: Brønsted Acid Catalyzed Reactions of Aromatic Ketones with Ethyl Diazoacetate and Its Synthetic Scope
Jahan, Khorshada (2021-12-01)PART I: A CONCISE SYNTHESIS OF MICROTUBULE INHIBITOR TRYPROSTATIN A AND B AND ITS ANALOGSMicrotubules are promising targets for treating cancer by stopping the cell division in mitosis(M). Tryprostatins A and B (TPS A and ... -
Short Synthesis and Biological Evaluation of 5-chloro-7-benzoyl 2,3-dihydrobenzo[b]furan -3-carboxylic Acid(brl-37959) and Its Analogs.
Ahmed, Shamsul Arefin (2017-12-01)The synthesis of BRL-37959 has previously been reported. As an NSAID, the compound was tested for and found that it had very low gastric irritancy. Commercially available NSAIDs are non-selective COX inhibitors that enhance ... -
Shorter and Improved Access to the Key Tetracyclic Core of Sarpagine-Macroline-Ajmaline Indole Alkaloids: the Total Synthesis of Alkaloids Macrocarpines A-g, Talcarpine, N(4)-methyl-n(4),21-secotalpinine, Deoxyperaksine, Dihydroperaksine, Talpinine, O-acetyltalpinine, and N(4)-methyltalpinine
Rahman, Md Toufiqur (2018-12-01)Extension of the asymmetric Pictet-Spengler (P-S) reaction to bulkier Nb-alkylated tryptophan derivatives resulted in a shorter and improved stereospecific access to the key bicyclo[3.3.1]nonane framework of bioactive C-19 ...