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Transmission ratio distortion in the hybrid offspring of three mouse subspecies

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dc.contributor.advisor Payseur, Bret A. (Mentor)
dc.contributor.author Wagner, Jennifer Margaret
dc.date.accessioned 2010-07-21T17:32:26Z
dc.date.available 2010-07-21T17:32:26Z
dc.date.issued 2010
dc.identifier.uri http://digital.library.wisc.edu/1793/46044
dc.description 54 p. en
dc.description.abstract A crucial component of understanding the origin or new species is understanding how reproductive isolation evolves between divergent populations. The relative importance of Dobzhansky-Muller incompatibilities as compared to meiotic drivers in the origin of post-zygotic isolation therefore represents an important question in evolutionary biology. This study begins answering that question by identifying regions of significant transmission ratio distortion (TRD) in the F2 progeny of reciprocal intercrosses conducted between three wild-derived inbred mouse (Mus musculus) strains: WSB/EiJ, PWD/PhJ, and CAST/EiJ. Analysis of genotype data at 212 autosomal single nucleotide polymorphisms (SNPs) from across the genome revealed eleven significantly distorted regions in a WSB/EiJ X PWD/PhJ reciprocal intercross, of which seven were sex-specific, and eight significantly distorted regions in a WSB/EiJ X CAST/EiJ reciprocal intercross, of which all were sex-specific. Increased levels of TRD observed in the WSB/EiJ X PWD/PhJ reciprocal intercross as compared to the WSB/EiJ X CAST/EiJ reciprocal intercross suggest greater functional divergence of M. m. musculus than M. m. casteneus from M. m. domesticus. Additionally, the observation that the majority of TRD is sex-specific indicates that the sex chromosomes are important in establishing post-zygotic reproductive isolation. Based on the TRD found, as well as the sex ratios observed in each cross, it seems likely that Dobzhansky-Muller incompatibilities play a more important role than meiotic drivers in the origin of post-zygotic isolation in house mice. en
dc.description.provenance Submitted by Beverly Phillips (bphillips@library.wisc.edu) on 2010-07-21T15:46:13Z No. of bitstreams: 1 2010_Wagner.pdf: 2458091 bytes, checksum: 8fa8828bbcd2bd3157b39824fadd6d64 (MD5) en
dc.description.provenance Approved for entry into archive by Beverly Phillips(bphillips@library.wisc.edu) on 2010-07-21T17:32:26Z (GMT) No. of bitstreams: 1 2010_Wagner.pdf: 2458091 bytes, checksum: 8fa8828bbcd2bd3157b39824fadd6d64 (MD5) en
dc.description.provenance Made available in DSpace on 2010-07-21T17:32:26Z (GMT). No. of bitstreams: 1 2010_Wagner.pdf: 2458091 bytes, checksum: 8fa8828bbcd2bd3157b39824fadd6d64 (MD5) Previous issue date: 2010 en
dc.language.iso en_US en
dc.rights The author grants to the University of Wisconsin-Madison the permission to reproduce and to distribute publicly paper and electronic copies of this thesis document in whole or in part in any medium now known or hereafter created. en
dc.subject Microbiology en
dc.subject Genetics en
dc.title Transmission ratio distortion in the hybrid offspring of three mouse subspecies en
dc.type Thesis en
thesis.degree.level BS en

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