| dc.contributor.advisor |
Parkin, Kirk (Mentor) |
|
| dc.contributor.author |
Chan, Lok Yan |
|
| dc.date.accessioned |
2010-01-21T19:13:02Z |
|
| dc.date.available |
2010-01-21T19:13:02Z |
|
| dc.date.issued |
2010 |
|
| dc.identifier.uri |
http://digital.library.wisc.edu/1793/38592 |
|
| dc.description |
13 p. |
en |
| dc.description.abstract |
Excessive inflammatory response is implicated in many diseases such as arthritis, atherosclerosis, and cardiomyopathy. Previous studies have found that several cinnamon species could exhibit anti-inflammatory activities. Adopting the bioassay-guided purification technique, trans-cinnamaldehyde was identified to be the principle active component in Cinnamomum burmannii. At a dosage of 50 muM, trans-cinnamaldehyde could inhibit 50% production of nitric oxide by down-regulating the expression of iNOS. It also inhibited 75% of prostaglandin E2 (PGE2) production without changing cyclooxygenase-2 (COX-2) protein expression. It was concluded that trans-cinnamaldehyde was the major component in C. burmannii responsible for its anti-inflammatory activity through inhibition of NO and PGE2 production. |
en |
| dc.description.provenance |
Submitted by Beverly Phillips (bphillips@library.wisc.edu) on 2010-01-21T19:11:48Z
No. of bitstreams: 1
2010_Chan.pdf: 763479 bytes, checksum: 6b9dc4a7322593953a9f0d36abd48494 (MD5) |
en |
| dc.description.provenance |
Approved for entry into archive by Beverly Phillips(bphillips@library.wisc.edu) on 2010-01-21T19:13:02Z (GMT) No. of bitstreams: 1
2010_Chan.pdf: 763479 bytes, checksum: 6b9dc4a7322593953a9f0d36abd48494 (MD5) |
en |
| dc.description.provenance |
Made available in DSpace on 2010-01-21T19:13:02Z (GMT). No. of bitstreams: 1
2010_Chan.pdf: 763479 bytes, checksum: 6b9dc4a7322593953a9f0d36abd48494 (MD5)
Previous issue date: 2010 |
en |
| dc.language.iso |
en_US |
en |
| dc.subject |
Food Science |
en |
| dc.subject |
Biochemistry |
en |
| dc.title |
Bioassay-guided purification and characterization of anti-inflammatory components in Cinnamomum burmannii |
en |
| dc.type |
Thesis |
en |
| thesis.degree.level |
BS |
en |
| thesis.degree.discipline |
Biochemistry |
en |
