| dc.contributor.advisor |
Hati, Sanchita |
|
| dc.contributor.advisor |
Bhattacharyay, Sudeep |
|
| dc.contributor.author |
Weimer, Kristina |
|
| dc.contributor.author |
Shane, Brianne |
|
| dc.contributor.author |
Brunetto, Michael |
|
| dc.date.accessioned |
2009-02-11T20:02:25Z |
|
| dc.date.available |
2009-02-11T20:02:25Z |
|
| dc.date.issued |
2009-02-11T20:02:25Z |
|
| dc.identifier.uri |
http://digital.library.wisc.edu/1793/32284 |
|
| dc.description |
Color poster with text and disgrams describing research conducted by Kristina Weimer, Brianne Shane, and Michael Brunetto, advised by Sudeep Bhattacharyay and Sanchita Hati. |
en |
| dc.description.abstract |
Leucyl-tRNA synthetases are class I synthetases that catalyze the covalent attachment of leucine to the tRNAL. The three-dimensional crystal structure of Thermus thermophilus leucyl-tRNA synthetase (TtLeuRS) demonstrates a complex modular architecture where three flexible domains [the conserved connective polypeptide 1 (CP1) domain (residues 224-417), the leucine-specific (LS) domain (residues 577-634), and the zinc-1 (ZN-1) binding domain (residues 154-189)] are inserted into the central catalytic domain. In the present work, we have investigated the collective motion of various structural elements in TtLeuRS using normal mode calculations. |
en |
| dc.description.provenance |
Submitted by Randy Olson (olsonran@uwec.edu) on 2009-02-11T20:02:25Z
No. of bitstreams: 2
WeimerSpr08.pptx: 5372157 bytes, checksum: f5ce765d49271f6e2449a558e78d5493 (MD5)
WeimerSpr08.pdf: 1596781 bytes, checksum: d012e61d5df5b95382e25c5d5247f780 (MD5) |
en |
| dc.description.provenance |
Made available in DSpace on 2009-02-11T20:02:25Z (GMT). No. of bitstreams: 2
WeimerSpr08.pptx: 5372157 bytes, checksum: f5ce765d49271f6e2449a558e78d5493 (MD5)
WeimerSpr08.pdf: 1596781 bytes, checksum: d012e61d5df5b95382e25c5d5247f780 (MD5) |
en |
| dc.description.sponsorship |
University of Wisconsin--Eau Claire Office of Research and Sponsored Programs. |
en |
| dc.language.iso |
en_US |
en |
| dc.relation.ispartofseries |
USGZE AS589 |
en |
| dc.subject |
RNA |
en |
| dc.subject |
Aminoacyl-tRNA synthetase |
en |
| dc.subject |
Leucine |
en |
| dc.subject |
Amino acids |
en |
| dc.subject |
Posters |
en |
| dc.title |
Exploring Cooperative Domain Dynamics in Thermus thermophilus Leucyl-tRNA Synthetase Using Low-Frequency Normal Mode Calculations and Statistical Coupling Analysis. |
en |
| dc.type |
Presentation |
en |
