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Biochemistry Honors Theses and Research Papers >
Please use this identifier to cite or link to this item:
http://digital.library.wisc.edu/1793/23549
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| Title: | MHC class I allele characterization in Indonesian cynomolgus macaques |
| Authors: | Pendley, Chad |
| Advisors: | O’Connor, Shelby L. (Mentor) |
| Keywords: | Biochemistry
Pathology and Laboratory Medicine |
| Issue Date: | 2007 |
| Abstract: | There has recently been increased interest in the use of cynomolgus macaques for the study of infectious diseases. However, little focus has been given to studying the immunogenetics of these animals. To improve researcher’s understanding and utilization of these model organisms, we characterized 48 full length MHC (Major Histocompability Complex) alleles in Indonesian cynomolgus macaques via cloning and sequencing. Furthermore, we found that three of these alleles were originally found in cynomolgus macaques of Mauritian origin, supporting the hypothesis that Mauritian animals originally came from Indonesia. The Mauritian alleles, Mafa-B*4501,Mafa-B*5101, and Mafa-B*1201 present in 19%, 7% and 4% of our cohort respectively according to PCRSSP results. |
| Description: | 12 p. |
| URI: | http://digital.library.wisc.edu/1793/23549 |
| Appears in Collections: | Biochemistry Honors Theses and Research Papers
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Files in This Item:
| File |
Description |
Size | Format | Handle |
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| 2007_Pendley.pdf | | 272Kb | Adobe PDF | http://digital.library.wisc.edu/1793/23550 | View/Open |
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