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Importance of CCW12 gene expression in zinc deficient Saccharomyces cerevisiae

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Author(s)
Mateo, Michael
Advisor(s)
Eide, David
Date
2007
Subject(s)
Nutritional Sciences
Abstract
Pathogenic fungi have a major impact on human health. There is a lack of good therapies and some pathogenic fungi are resistant to the existing treatments. One possible target for treatment is covalently bonded cell wall protein 12 (CCW12), which is a cell wall protein that is needed for structural stability of the fungal cell wall. CCW12 is also induced in low zinc conditions by Zap1, which is a protein that is involved in transcriptional regulation in response to zinc. The goal of this study was to determine why CCW12 is up-regulated in low zinc conditions by Zap1. A number of experiments were conducted and seem to indicate that the CCW12 is up-regulated in low zinc to help stabilize the cell wall. More studies should be done to clarify the role of CCW12 and to investigate possible treatment for fungal infections.
Description
17 p.
Permanent link
http://digital.library.wisc.edu/1793/18285 
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