Browsing by Author "Yamane, B"
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Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting
Reisfeld, RA; Gillies, SD; Rakhmilevich, AL; Yamane, B; Hank, JA; Gubbels, JA; Patankar, MS; Buhtoiarov, TN; Gan, J; Buhtoiarov, IN; Neal, ZC; Sondel, PM (2011-04)The hu14.18-IL2 (EMD 273063) IC, consisting of a GD(2)-specific mAb genetically engineered to two molecules of IL-2, is in clinical trials for treatment of GD(2)-expressing tumors. Anti-tumor activity of IC in vivo and in ...